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Increasing NAD+
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<blockquote data-quote="Will Brink" data-source="post: 145050" data-attributes="member: 2074"><p>Great show, A good discussion on NAD, NAD precursors, etc.</p><p></p><p>Note at 1:27 in the show discussion of papers finding NR was superior to niacinamide for NAD levels in muscle tissue and all important mention of tissue specific kinetic flux.</p><p></p><p>At 1:28, discussion of the rational as to why taking NR is still the most effective route to increasing tissue NAD levels.</p><p></p><p>1:29 <strong>why taking niacinamide may in fact<em> be a negative</em> "liability" to increasing whole body tissue NAD levels! </strong></p><p></p><p>They are not supportive of infusions however, but the reasons why are most theoretical vs established.</p><p></p><p>As I had said in the other thread, it's not as simple as the OP thinks it is, and I recommend everyone interested in the topic listen to this show, paying close attention to the sections above...</p><p></p><p>What they didn't discuss why tissue levels drop to nadda as we age:</p><p></p><p>Is it poor conversion of niacinamide to NAD via age related mechanisms?</p><p>Increase in degradation of NAD and system can't produce it fast enough?</p><p>Simple lack of adequate substrate (niacinamide) in the diet as we age?</p><p>Poor absorption of niacinamide and other subtstrates from digestion? (1)</p><p>Other?</p><p></p><p>Finally, they discuss the benefits and importance of creatine for methylation (2:11 of show), something I have been for several decades now and one of various reasons creatine is a general health promoting anti aging supplement <em>vertually anyone</em> will benefit from. I also suspect creatine increases NAD+ levels, but I have not found the data to show that yet.</p><p></p><p>(1) Note the guest posits only NR appears to get absorbed without conversion to niacinamide or other intermediates.</p></blockquote><p></p>
[QUOTE="Will Brink, post: 145050, member: 2074"] Great show, A good discussion on NAD, NAD precursors, etc. Note at 1:27 in the show discussion of papers finding NR was superior to niacinamide for NAD levels in muscle tissue and all important mention of tissue specific kinetic flux. At 1:28, discussion of the rational as to why taking NR is still the most effective route to increasing tissue NAD levels. 1:29 [B]why taking niacinamide may in fact[I] be a negative[/I] "liability" to increasing whole body tissue NAD levels! [/B] They are not supportive of infusions however, but the reasons why are most theoretical vs established. As I had said in the other thread, it's not as simple as the OP thinks it is, and I recommend everyone interested in the topic listen to this show, paying close attention to the sections above... What they didn't discuss why tissue levels drop to nadda as we age: Is it poor conversion of niacinamide to NAD via age related mechanisms? Increase in degradation of NAD and system can't produce it fast enough? Simple lack of adequate substrate (niacinamide) in the diet as we age? Poor absorption of niacinamide and other subtstrates from digestion? (1) Other? Finally, they discuss the benefits and importance of creatine for methylation (2:11 of show), something I have been for several decades now and one of various reasons creatine is a general health promoting anti aging supplement [I]vertually anyone[/I] will benefit from. I also suspect creatine increases NAD+ levels, but I have not found the data to show that yet. (1) Note the guest posits only NR appears to get absorbed without conversion to niacinamide or other intermediates. [/QUOTE]
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