Increased libido then nothing

LowTman

New Member
Hey guys, I’m a 61 year old retired Navy nurse. My wife insisted a start trt due to zero libido. Labs confirmed I was low (229) and after starting in 100 mg cypionate weekly, three weeks later I was like wow wee! There was serious passion in the BR. Unfortunately, 3 months into it, I seem to have declining libido along with increase OSA symptoms. Could my free testosterone be low? My 6 week lab follow up (done 5 days post injection) showed a total testosterone 645 in Mid August, it’s now 3 November. I’m wondering if available testosterone is low & total T is converting to estradiol. Any suggestions? I do follow up labs on 23 December.
 
Labs confirmed I was low (229) and after starting in 100 mg cypionate weekly, three weeks later I was like wow wee!
The spikes in T on injectable T is very unnatural (long and gradual) and therefore has the potential to cause problems in certain individuals.

Also guys that start out higher than what was natural for them has the potential to cause numerous side effects, one such example is the body down-regulates to protect itself from an onslaught of hormonal signaling.

If you spend enough time on this forum, you'll start to see various men on different protocols and that's because hormone response is unique to the individual.
 
Last edited:
My 6 week lab follow up (done 5 days post injection) showed a total testosterone 645 in Mid August
What your labs didn't show was the large difference between peak and trough levels.

Take a guy and split his dosage up daily and the hormone profile and mg release is miles apart even if the levels are the same.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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