Increase in PSA with age

My rectal exam was about 1.5 years ago and they said I was good. But does PSA actually go up with age? No, I am not treated for BPH. Is there a chance that it goes up during TRT?
 
PSA levels does increase with age. The reason they go up as you age is not related to prostate cancer. It's an enlargement of the prostate and as obviously as your prostate gets bigger, your chance of having PSA levels higher as you age increases. So therefore, men that get older typically have higher PSA levels.
 
Doctors will keep a close eye on your psa during TRT (they should keep a close eye on it under any circumstances). Yours is on the high side. Should it reach 4.0 TRT is typically stopped while further investigations are undertaken.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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