Importance of free testosterone measurement in assesssing androgen disorders

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Testosterone imbalances affect men, women, and children differently. In males, testosterone deficiency (hypogonadism) can lead to low libido, fatigue, and muscle loss, while excess may contribute to aggression and cardiovascular risks. In females, testosterone excess (hyperandrogenism), often associated with polycystic ovary syndrome (PCOS) or adrenal disorders, can cause excess hair growth, weight gain, and menstrual irregularities. In children, deficiency delays puberty, while excess may result in early puberty or virilization. Accurate diagnosis and management rely on accurate testosterone testing, with free testosterone measurement playing a critical role in evaluating androgen disorders.


Dr. Sandeep Dhindsa explores the significance of free testosterone measurements in diagnosing and managing androgen disorders.





WEBINAR

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Speaker:

Sandeep Dhindsa, MD

Sandeep Dhindsa, MD

Chief, Division of Endocrinology and Metabolism, Clara A. Drefs Chair in Internal Medicine, Saint Louis University

Dr. Sandeep Dhindsa is Professor of Medicine (with tenure) and Chief of the Division of Endocrinology and Metabolism at Saint Louis University.

He completed his medical schooling from All India Institute of Medical Sciences in New Delhi, India. He did residency in Internal medicine from State University of New York at Brooklyn and fellowship in Endocrinology from University at Buffalo, NY.

His primary area of research is hypogonadism in men with obesity and diabetes. He has served as the primary investigator on a grant from the American Diabetes Association and co-investigator on a grant from NIH to elucidate the effects of hypogonadism in men with type 2 diabetes or obesity on insulin sensitivity and inflammation and the response to treatment with testosterone.

He has over 100 publications in peer-review journals. He is frequently invited to give lectures on male hypogonadism in national and international meetings. He is an associate editor for journal “Frontiers in Endocrinology”. He is a member of the board of directors for the Androgen Society. He is a member of Saint Louis University IRB.

He has served as Associate Editor of the journal “Androgens: Clinical Research and Therapeutics” and was vice chair of the Reproductive Endocrinology Scientific Committee of American Association of Clinical Endocrinologists.
 
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Critical points that need to be hammered home here!


Opportunities for improvement


* Harmonize free testosterone reference ranges across laboratories

* Ensure that only accurate free testosterone assays remain on the market

* Free testosterone should be the predominant laboratory parameter to assesss hypogonadism, not total testosterone




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