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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Ideally mimicking the body's testosterone process
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<blockquote data-quote="johndoesmith" data-source="post: 61254" data-attributes="member: 13404"><p>. </p><p></p><p>Good! That's why you will continue to learn. Those that get upset when presented with facts will not continue to learn or they will look for "alternative facts". </p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p>Yeah, I can't substantiate my claims that men don't feel different at 8am vs 10pm in terms of testosterone related feelings, and it would probably be hard to control for other factors such as being tired in the AM vs PM for different people. </p><p></p><p>I can tell you before I had symptoms, I felt no different AM vs PM in terms of sexual symptoms. </p><p></p><p>Plus, my understanding of nuclear receptor mediated effects vs GPCR mediated effects is that the former are much slower to notice. It isn't like other drugs wearing off where you can feel it, such as caffeine, alcohol, or pain medicine.</p><p></p><p></p><p></p><p></p><p>It would be very difficult to control E2, get labs, and since testosterone doesn't cause effects quickly, I cannot see a reason for it. </p><p></p><p>I can only see negatives without any benefits. </p><p></p><p></p><p></p><p>Now I don't know the mechanism that prevents androgen receptors from downregulating like GPCRs and other more recreational drugs, but there isn't any evidence of this happening. </p><p></p><p>Many men here, such as nelson vergel, have been on TRT for years with seemingly no reported loss of effectivity.</p></blockquote><p></p>
[QUOTE="johndoesmith, post: 61254, member: 13404"] . Good! That's why you will continue to learn. Those that get upset when presented with facts will not continue to learn or they will look for "alternative facts". Yeah, I can't substantiate my claims that men don't feel different at 8am vs 10pm in terms of testosterone related feelings, and it would probably be hard to control for other factors such as being tired in the AM vs PM for different people. I can tell you before I had symptoms, I felt no different AM vs PM in terms of sexual symptoms. Plus, my understanding of nuclear receptor mediated effects vs GPCR mediated effects is that the former are much slower to notice. It isn't like other drugs wearing off where you can feel it, such as caffeine, alcohol, or pain medicine. It would be very difficult to control E2, get labs, and since testosterone doesn't cause effects quickly, I cannot see a reason for it. I can only see negatives without any benefits. Now I don't know the mechanism that prevents androgen receptors from downregulating like GPCRs and other more recreational drugs, but there isn't any evidence of this happening. Many men here, such as nelson vergel, have been on TRT for years with seemingly no reported loss of effectivity. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Ideally mimicking the body's testosterone process
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