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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Ideally mimicking the body's testosterone process
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<blockquote data-quote="johndoesmith" data-source="post: 61248" data-attributes="member: 13404"><p>No we can't. I am not aware of any evidence that natural guys feel better in the AM vs PM due to testosterone levels being higher. </p><p></p><p>E2 does not vary in the natty guy due to diurnal fluctuations of testosterone. </p><p></p><p>[ATTACH]3124[/ATTACH]</p><p></p><p>Plus, what you're describing as "tolerance" would be what's called "downregulation" in pharmacology. There isn't evidence of this occurring, and in fact there's evidence that androgens upregulate androgen receptors, although usually in supraphysiological doses.</p><p></p><p>Another thing, there is some variation even on E3.5D injection protocols. The amount of which will vary from guy to guy, but it is there, I've tested 48h and 72h after injection and I see a 200-300ng/dl difference. </p><p></p><p>"confusing" the body, essentially is not how it works, and isn't correct. Changing doses, especially in the way of increasing them is called "blasting". Of course I don't think you meant it that way. </p><p></p><p>I don't mean to come off rude, harsh, or crass, you seem genuinely curious and have decent questions. That's great, we need more of that in the world.</p></blockquote><p></p>
[QUOTE="johndoesmith, post: 61248, member: 13404"] No we can't. I am not aware of any evidence that natural guys feel better in the AM vs PM due to testosterone levels being higher. E2 does not vary in the natty guy due to diurnal fluctuations of testosterone. [ATTACH=CONFIG]3124[/ATTACH] Plus, what you're describing as "tolerance" would be what's called "downregulation" in pharmacology. There isn't evidence of this occurring, and in fact there's evidence that androgens upregulate androgen receptors, although usually in supraphysiological doses. Another thing, there is some variation even on E3.5D injection protocols. The amount of which will vary from guy to guy, but it is there, I've tested 48h and 72h after injection and I see a 200-300ng/dl difference. "confusing" the body, essentially is not how it works, and isn't correct. Changing doses, especially in the way of increasing them is called "blasting". Of course I don't think you meant it that way. I don't mean to come off rude, harsh, or crass, you seem genuinely curious and have decent questions. That's great, we need more of that in the world. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Ideally mimicking the body's testosterone process
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