I experienced profound anxiety with compounded HCG from Empower, but since I switched to Novarel I have had zero of the negative subjective symptoms (anxiety, etc.). I used Empower on and off for 2 years before switching to Novarel. Have been using Novarel for about a year and would never even consider going back.
It may be estradiol related. However, it may be worth switching brands to see if there is a subjective difference in response.
