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At least for me, the saturation dose of hCG for estradiol production is relatively low. This means that when taking anywhere from 470-1,050 IU per week I see a rise of nearly 20 pg/mL in estradiol. If estradiol is contributing to your anxiety then this may be the reason. Conventional wisdom says that 500 IU per week is about the minimum needed to maintain benefits. Yet there are anecdotal reports of guys taking only 250 IU once a week with reasonable results. If you'd like to continue using hCG then you may need to experiment with lower doses.
