How to treat obesity and hypogonadism; The male hormone reset

[madman]

Professor Michael Zitzmann

Testosterone Deficiency (TD). and its Effects

Thread 'The male hormone reset: how GLP-1RAs, lifestyle and testosterone transform obesity-linked problems'

Dec 16, 2025

Figure 1. Comparative overview of therapeutic approaches for male hypogonadism and metabolic dysfunction. The figure summarizes the key advantages and disadvantages of three main management modalities: GLP-1 receptor agonists (GLP-1 RAs), lifestyle modification (diet and exercise), and testosterone therapy (TTh). GLP-1 RAs provide substantial weight loss and cardiovascular benefit but may lead to muscle loss, mood disturbances, and rebound weight gain upon discontinuation. Diet and exercise remain foundational but are limited by adherence challenges. Testosterone therapy exerts...

• madman
• hypogonadism; obesity; glp-1; t-therapy; lifestyle
• Replies: 1
• Forum: Testosterone and Men's Health Articles

 

[madman]

Prevalence of Hypogonadism in 1667 Men presenting to an Outpatient Andrology Unit

 

[madman]

Professor Michael Zitzmann

* When someone changes from obesity to a normal stature, we might find that actually also the mortality risk is decreased

Lower T: Higher Mortality

 

[madman]

How does visceral fat affect all this?

 

[madman]

Functional TD and associated diseases

 

[madman]

Effects of Weight Loss on Testosterone Levels

WHY ALL THIS EFFORT?

 

[madman]

How do. GLP-1 Receptor Agonists work?

Effects of GLP-1 - Receptor Agonists

 

[madman]

GLP-1 RAs: Dosing and Effect

GLP-1 RAs: Dose Escalation Schedule

Effects of GLP 1 RAs on Cardiovascular Risk

 

[madman]

What does Tirzepatid do to the pituitary-gonadal axis?

Effects on erectile function

Meta-Analysis: GLP 1 RAs and Testosterone

 

[madman]

Side effects of GLP 1 RAs

 

[madman]

Isn't muscle mass lost, as well?

Sports

Nutrition

 

[madman]

What is Bimagrumab? Thought to be added to Tirzepatide

TRIAL STOPPED due to. side-effects

 

[madman]

Bhasin's groundbreaking 96 study!

 

[madman]

GLP1-RAs/Diet + Exercise/Testosterone