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General Health & Fitness
Nutrition and Supplements
How Much Is Needed for Vitamin D?
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<blockquote data-quote="Will Brink" data-source="post: 114161" data-attributes="member: 2074"><p>I don't see that many labs offering that test. No doubt will increase now that it's importance is gets better known. There does appear to be some debate as to the value of of testing <span style="color: #333333">1,25-Dihydroxy as an indicator of D status in healthy people however:</span></p><p><span style="color: #333333"></span></p><p><span style="color: #333333">"Many practitioners become confused when ordering a vitamin D test. Because 1,25-dihydroxyvitamin D is the active form of vitamin D, many practitioners think that measuring 1,25-dihydroxyvitamin D is an accurate means to estimate vitamin D stores and test for vitamin D deficiency, which is incorrect. Current Endocrine Society guidelines recommend screening for vitamin D deficiency in individuals at risk for deficiency. Serum levels of 1,25-dihyroxyvitamin D have little or no relationship to vitamin D stores but rather are regulated primarily by parathyroid hormone levels, which in turn are regulated by calcium and/or vitamin D. In vitamin D deficiency, 1,25-dihydroxyvitamin D levels go up, not down. Unregulated production of 1,25-dihydroxyvitamin D (i.e., sarcoidosis, granulomatous diseases) is an uncommon cause of hypercalcemia; this should be suspected if blood calcium levels are high and parathyroid hormone levels are low and confirmed by measurement of 1,25-dihydroxyvitamin D. The enzyme that activates vitamin D is produced in the kidney, so blood levels of 1,25-dihydroxyvitamin D are sometimes of interest in patients on dialysis or with end-stage kidney disease. There are few other circumstances, if any, where 1,25-dihydroxyvitamin D testing would be helpful. Serum 25-hydroxyvitamin D levels may be overused, but when trying to assess vitamin D stores or diagnose vitamin D deficiency (or toxicity), 25-hydroxyvitamin D is the correct test."</span></p><p><span style="color: #333333"></span></p><p><span style="color: #333333"><a href="https://www.aafp.org/afp/recommendations/viewRecommendation.htm?recommendationId=140" target="_blank">https://www.aafp.org/afp/recommendations/viewRecommendation.htm?recommendationId=140</a></span></p><p><span style="color: #333333"></span></p></blockquote><p></p>
[QUOTE="Will Brink, post: 114161, member: 2074"] I don't see that many labs offering that test. No doubt will increase now that it's importance is gets better known. There does appear to be some debate as to the value of of testing [COLOR=#333333]1,25-Dihydroxy as an indicator of D status in healthy people however: "Many practitioners become confused when ordering a vitamin D test. Because 1,25-dihydroxyvitamin D is the active form of vitamin D, many practitioners think that measuring 1,25-dihydroxyvitamin D is an accurate means to estimate vitamin D stores and test for vitamin D deficiency, which is incorrect. Current Endocrine Society guidelines recommend screening for vitamin D deficiency in individuals at risk for deficiency. Serum levels of 1,25-dihyroxyvitamin D have little or no relationship to vitamin D stores but rather are regulated primarily by parathyroid hormone levels, which in turn are regulated by calcium and/or vitamin D. In vitamin D deficiency, 1,25-dihydroxyvitamin D levels go up, not down. Unregulated production of 1,25-dihydroxyvitamin D (i.e., sarcoidosis, granulomatous diseases) is an uncommon cause of hypercalcemia; this should be suspected if blood calcium levels are high and parathyroid hormone levels are low and confirmed by measurement of 1,25-dihydroxyvitamin D. The enzyme that activates vitamin D is produced in the kidney, so blood levels of 1,25-dihydroxyvitamin D are sometimes of interest in patients on dialysis or with end-stage kidney disease. There are few other circumstances, if any, where 1,25-dihydroxyvitamin D testing would be helpful. Serum 25-hydroxyvitamin D levels may be overused, but when trying to assess vitamin D stores or diagnose vitamin D deficiency (or toxicity), 25-hydroxyvitamin D is the correct test." [URL]https://www.aafp.org/afp/recommendations/viewRecommendation.htm?recommendationId=140[/URL] [/COLOR] [/QUOTE]
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General Health & Fitness
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How Much Is Needed for Vitamin D?
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