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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How many mg are we really getting ?
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<blockquote data-quote="Cataceous" data-source="post: 217260" data-attributes="member: 38109"><p>As I was just arguing in another thread, it's part of the legacy of large and infrequent injections. There's greater focus on trough serum testosterone, so that's typically what drives the dose. But if you're injecting testosterone cypionate only once a week then its five-day half-life means your serum peak could be two to three times higher than the trough. So, for example, you dose to get a trough of 600 ng/dL, which ignores the peak of 1,500 earlier in the cycle. The preferred solution is to increase the injection frequency so that the excursions in serum testosterone are limited to physiological levels. A dose of 50 mg per week would be ok for many men if spread out over the week—I'm on the equivalent of 44 mg, for example. 75 mg would be closer to average. But as a single injection per week it's not likely to work well for most, given the low trough levels they'd experience.</p><p></p><p>As for the guys seeing only average total testosterone from very high doses, they likely have low SHBG, which has been made more so by the high doses. Their free testosterone is going to be quite high. It's possible some men have higher metabolic clearance rates for testosterone, which amplifies the issue. But my guess is that this isn't so common.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 217260, member: 38109"] As I was just arguing in another thread, it's part of the legacy of large and infrequent injections. There's greater focus on trough serum testosterone, so that's typically what drives the dose. But if you're injecting testosterone cypionate only once a week then its five-day half-life means your serum peak could be two to three times higher than the trough. So, for example, you dose to get a trough of 600 ng/dL, which ignores the peak of 1,500 earlier in the cycle. The preferred solution is to increase the injection frequency so that the excursions in serum testosterone are limited to physiological levels. A dose of 50 mg per week would be ok for many men if spread out over the week—I'm on the equivalent of 44 mg, for example. 75 mg would be closer to average. But as a single injection per week it's not likely to work well for most, given the low trough levels they'd experience. As for the guys seeing only average total testosterone from very high doses, they likely have low SHBG, which has been made more so by the high doses. Their free testosterone is going to be quite high. It's possible some men have higher metabolic clearance rates for testosterone, which amplifies the issue. But my guess is that this isn't so common. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How many mg are we really getting ?
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