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Anecdotally, a lot of the steroid (ab)users seem to think a testosterone surge helps, though their doses are much bigger. This has led to widespread availability of TNE (testosterone no-ester), which should act similarly to Natesto if doses are kept sane. Leading to:

I have experimented with 1-3 mg of TNE enough to believe there is an effect. It seems to be delayed by some hours, and oddly carries over into the next 2-3 days. This suggests to me that the testosterone pulse triggers secondary effects that endure much longer than the surge in serum testosterone.