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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How do athletes microdose without suppressing natural T?
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<blockquote data-quote="Willyt" data-source="post: 173310" data-attributes="member: 38668"><p>Many thanks all and Cataceous for the Natesto reference. Jumping down that rabbit hole now. Your comment on how its more about the trough then the peak makes a lot of sense. I may have to revise my thinking above about the thermostat “set point.”</p><p></p><p>Interesting quotes from a few of the Natesto threads:</p><p><em></em></p><p><em>“Surge in high physiological levels of testosterone will peak within 45 minutes post application (half-life 10-100 min).</em></p><p><em></em></p><p><em>Each dose of NATESTO® resulted in a short-term return of testosterone to the upper normal range (800 ng/dL; 28 nmol/L) irrespective of how low the patient’s baseline testosterone was prior to the study.</em></p><p><em></em></p><p><em>Based on the data, Acerus believes that the mechanism of action of NATESTO® is unique whereby the peaks in testosterone generated by NATESTO® dosing provide efficacy and improvement of symptoms, while the time between doses (4-8 hours) allows for the maintenance of testicular testosterone production and sperm production.</em></p><p><em></em></p><p><em>The release of testosterone with NATESTO® is pulsatile - closely matching the bodies "natural" testosterone release. Consequently, NATESTO® does not suppress a man's natural testosterone level, but simply adds to it to achieve a normal, safe level of testosterone.”</em></p><p></p><p>For any future Olympian dopers, looks like you’ll get busted for Natesto! LOL</p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/27714988" target="_blank">Intranasal delivery of Natesto® testosterone gel and its effects on doping markers. - PubMed - NCBI</a></p><p></p><p>Natesto seems to getting mixed reviews from a few forum members here. Shooting that spray up your nose 3x per day could get tedious. Still very interesting though for intermittent use.</p><p></p><p><strong>Do you think there would be any muscle building benefit to using Natesto 30-45 minutes before a heavy workout? </strong></p><p></p><p><strong>What about a short-term libido boost before sex?</strong></p></blockquote><p></p>
[QUOTE="Willyt, post: 173310, member: 38668"] Many thanks all and Cataceous for the Natesto reference. Jumping down that rabbit hole now. Your comment on how its more about the trough then the peak makes a lot of sense. I may have to revise my thinking above about the thermostat “set point.” Interesting quotes from a few of the Natesto threads: [I] “Surge in high physiological levels of testosterone will peak within 45 minutes post application (half-life 10-100 min). Each dose of NATESTO® resulted in a short-term return of testosterone to the upper normal range (800 ng/dL; 28 nmol/L) irrespective of how low the patient’s baseline testosterone was prior to the study. Based on the data, Acerus believes that the mechanism of action of NATESTO® is unique whereby the peaks in testosterone generated by NATESTO® dosing provide efficacy and improvement of symptoms, while the time between doses (4-8 hours) allows for the maintenance of testicular testosterone production and sperm production. The release of testosterone with NATESTO® is pulsatile - closely matching the bodies "natural" testosterone release. Consequently, NATESTO® does not suppress a man's natural testosterone level, but simply adds to it to achieve a normal, safe level of testosterone.”[/I] For any future Olympian dopers, looks like you’ll get busted for Natesto! LOL [URL="https://www.ncbi.nlm.nih.gov/pubmed/27714988"]Intranasal delivery of Natesto® testosterone gel and its effects on doping markers. - PubMed - NCBI[/URL] Natesto seems to getting mixed reviews from a few forum members here. Shooting that spray up your nose 3x per day could get tedious. Still very interesting though for intermittent use. [B]Do you think there would be any muscle building benefit to using Natesto 30-45 minutes before a heavy workout? [/B] [B]What about a short-term libido boost before sex?[/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
How do athletes microdose without suppressing natural T?
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