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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
How Can I Increase My Allopregnanolone ?
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<blockquote data-quote="Nelson Vergel" data-source="post: 59280" data-attributes="member: 3"><p>[ATTACH]2989[/ATTACH]</p><p>Metabolism of progesterone. Progesterone (P) is metabolized into allopregnanolone (A), a neuroactive steroid, in 2 steps. </p><p></p><p>Source: <a href="http://ajpregu.physiology.org/content/278/3/R684" target="_blank">http://ajpregu.physiology.org/content/278/3/R684</a></p><p></p><p></p><p>Anything that increases 5 alpha reductase (the same enzyme that converts testosterone to DHT) activity may increase allopregnanolone. HCG increases 5 alpha reductase. But be careful (read info below).</p><p></p><p>I got this info from wikipedia:</p><p></p><p><span style="color: #252525">Allopregnanolone possesses a wide variety of effects, including, in no particular order, <a href="https://en.wikipedia.org/wiki/Antidepressant" target="_blank">antidepressant</a>, <a href="https://en.wikipedia.org/wiki/Anxiolytic" target="_blank">anxiolytic</a>, <a href="https://en.wikipedia.org/wiki/Stress_(psychological)" target="_blank">stress-reducing</a>, <a href="https://en.wikipedia.org/wiki/Pleasure" target="_blank">rewarding</a>, <a href="https://en.wikipedia.org/wiki/Prosocial_behavior" target="_blank">prosocial</a>, <a href="https://en.wikipedia.org/wiki/Serenic" target="_blank">antiaggressive</a>, <a href="https://en.wikipedia.org/wiki/Aphrodisiac" target="_blank">prosexual</a>, <a href="https://en.wikipedia.org/wiki/Sedative" target="_blank">sedative</a>, <a href="https://en.wikipedia.org/wiki/Hypnotic" target="_blank">pro-sleep</a>, <a href="https://en.wikipedia.org/wiki/Cognitive_deficit" target="_blank">cognitive</a> and <a href="https://en.wikipedia.org/wiki/Cognitive_deficit" target="_blank">memory-impairing</a>, <a href="https://en.wikipedia.org/wiki/Analgesic" target="_blank">analgesic</a>, <a href="https://en.wikipedia.org/wiki/Anesthetic" target="_blank">anesthetic</a>, <a href="https://en.wikipedia.org/wiki/Anticonvulsant" target="_blank">anticonvulsant</a>, <a href="https://en.wikipedia.org/wiki/Neuroprotective" target="_blank">neuroprotective</a>, and <a href="https://en.wikipedia.org/wiki/Neurogenic" target="_blank">neurogenic</a> effects.</span></p><p><span style="color: #252525"></span></p><p><span style="color: #252525">Fluctuations in the levels of allopregnanolone and the other neurosteroids seem to play an important role in the pathophysiology of <a href="https://en.wikipedia.org/wiki/Depression_(mood)" target="_blank">mood</a>, <a href="https://en.wikipedia.org/wiki/Anxiety" target="_blank">anxiety</a>, <a href="https://en.wikipedia.org/wiki/Premenstrual_syndrome" target="_blank">premenstrual syndrome</a>, <a href="https://en.wikipedia.org/wiki/Catamenial_epilepsy" target="_blank">catamenial epilepsy</a>, and various other neuropsychiatric conditions.</span></p><p><span style="color: #252525"></span></p><p><span style="color: #252525">Increased levels of allopregnanolone can produce paradoxical effects, including <a href="https://en.wikipedia.org/wiki/Depression_(mood)" target="_blank">negative mood</a>, <a href="https://en.wikipedia.org/wiki/Anxiety" target="_blank">anxiety</a>, <a href="https://en.wikipedia.org/wiki/Irritability" target="_blank">irritability</a>, and <a href="https://en.wikipedia.org/wiki/Aggression" target="_blank">aggression</a>. This appears to be because allopregnanolone possesses biphasic, U-shaped actions at the GABA A receptor; moderate level increases inhibit the activity of the receptor, while lower and higher concentration increases stimulate it. This seems to be a common effect of many GABA receptor positive allosteric modulators. In accordance, acute administration of low doses of <a href="https://en.wikipedia.org/wiki/Micronized_progesterone" target="_blank">micronized progesterone</a> (which reliably elevates allopregnanolone levels), have been found to have negative effects on mood, while higher doses have a neutral effect.</span></p><p></p><p><a href="https://en.wikipedia.org/wiki/Exogenous" target="_blank">Exogenous</a> progesterone, such as <a href="https://en.wikipedia.org/wiki/Oral_administration" target="_blank">oral</a> progesterone, elevates allopregnanolone levels in the body with good dose-to-serum level correlations.<a href="https://en.wikipedia.org/wiki/Allopregnanolone#cite_note-pmid16406399-57" target="_blank">[57]</a> Due to this, it has been suggested that oral progesterone could be described as a <a href="https://en.wikipedia.org/wiki/Prodrug" target="_blank">prodrug</a> of sorts for allopregnanolone.<a href="https://en.wikipedia.org/wiki/Allopregnanolone#cite_note-pmid16406399-57" target="_blank">[57]</a> As a result, there has been some interest in using oral progesterone to treat catamenial epilepsy,<a href="https://en.wikipedia.org/wiki/Allopregnanolone#cite_note-DevinskySchachter2005-58" target="_blank">[58]</a> as well as other menstrual cycle-related and neurosteroid-associated conditions. In addition to oral progesterone, oral <a href="https://en.wikipedia.org/wiki/Pregnenolone" target="_blank">pregnenolone</a> has also been found to act as a prodrug of allopregnanolone,<a href="https://en.wikipedia.org/wiki/Allopregnanolone#cite_note-pmid15763596-59" target="_blank">[59]</a><a href="https://en.wikipedia.org/wiki/Allopregnanolone#cite_note-pmid21538944-60" target="_blank">[60]</a><a href="https://en.wikipedia.org/wiki/Allopregnanolone#cite_note-pmid23348009-61" target="_blank">[61]</a> though also of <a href="https://en.wikipedia.org/wiki/Pregnenolone_sulfate" target="_blank">pregnenolone sulfate</a>.<a href="https://en.wikipedia.org/wiki/Allopregnanolone#cite_note-pmid20570588-62" target="_blank">[62]</a></p><p></p><p></p><p><span style="color: #252525">Note: TRT shuts down LH which is essential in the production of pregnenolone and progesterone.</span></p><p></p><p><strong><a href="https://www.excelmale.com/forum/showthread.php?3990-Anabolic-steroids-and-TRT-decrease-SHBG-DHEA-pregnenolone-and-progesterone-in-men" target="_blank">Anabolic steroids and TRT decrease SHBG, DHEA, pregnenolone and progesterone in men.</a></strong></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 59280, member: 3"] [ATTACH alt="allopregnanolone.jpg"]2989[/ATTACH] Metabolism of progesterone. Progesterone (P) is metabolized into allopregnanolone (A), a neuroactive steroid, in 2 steps. Source: [URL]http://ajpregu.physiology.org/content/278/3/R684[/URL] Anything that increases 5 alpha reductase (the same enzyme that converts testosterone to DHT) activity may increase allopregnanolone. HCG increases 5 alpha reductase. But be careful (read info below). I got this info from wikipedia: [COLOR=#252525]Allopregnanolone possesses a wide variety of effects, including, in no particular order, [URL='https://en.wikipedia.org/wiki/Antidepressant']antidepressant[/URL], [URL='https://en.wikipedia.org/wiki/Anxiolytic']anxiolytic[/URL], [URL='https://en.wikipedia.org/wiki/Stress_(psychological)']stress-reducing[/URL], [URL='https://en.wikipedia.org/wiki/Pleasure']rewarding[/URL], [URL='https://en.wikipedia.org/wiki/Prosocial_behavior']prosocial[/URL], [URL='https://en.wikipedia.org/wiki/Serenic']antiaggressive[/URL], [URL='https://en.wikipedia.org/wiki/Aphrodisiac']prosexual[/URL], [URL='https://en.wikipedia.org/wiki/Sedative']sedative[/URL], [URL='https://en.wikipedia.org/wiki/Hypnotic']pro-sleep[/URL], [URL='https://en.wikipedia.org/wiki/Cognitive_deficit']cognitive[/URL] and [URL='https://en.wikipedia.org/wiki/Cognitive_deficit']memory-impairing[/URL], [URL='https://en.wikipedia.org/wiki/Analgesic']analgesic[/URL], [URL='https://en.wikipedia.org/wiki/Anesthetic']anesthetic[/URL], [URL='https://en.wikipedia.org/wiki/Anticonvulsant']anticonvulsant[/URL], [URL='https://en.wikipedia.org/wiki/Neuroprotective']neuroprotective[/URL], and [URL='https://en.wikipedia.org/wiki/Neurogenic']neurogenic[/URL] effects. Fluctuations in the levels of allopregnanolone and the other neurosteroids seem to play an important role in the pathophysiology of [URL='https://en.wikipedia.org/wiki/Depression_(mood)']mood[/URL], [URL='https://en.wikipedia.org/wiki/Anxiety']anxiety[/URL], [URL='https://en.wikipedia.org/wiki/Premenstrual_syndrome']premenstrual syndrome[/URL], [URL='https://en.wikipedia.org/wiki/Catamenial_epilepsy']catamenial epilepsy[/URL], and various other neuropsychiatric conditions. Increased levels of allopregnanolone can produce paradoxical effects, including [URL='https://en.wikipedia.org/wiki/Depression_(mood)']negative mood[/URL], [URL='https://en.wikipedia.org/wiki/Anxiety']anxiety[/URL], [URL='https://en.wikipedia.org/wiki/Irritability']irritability[/URL], and [URL='https://en.wikipedia.org/wiki/Aggression']aggression[/URL]. This appears to be because allopregnanolone possesses biphasic, U-shaped actions at the GABA A receptor; moderate level increases inhibit the activity of the receptor, while lower and higher concentration increases stimulate it. This seems to be a common effect of many GABA receptor positive allosteric modulators. In accordance, acute administration of low doses of [URL='https://en.wikipedia.org/wiki/Micronized_progesterone']micronized progesterone[/URL] (which reliably elevates allopregnanolone levels), have been found to have negative effects on mood, while higher doses have a neutral effect.[/COLOR] [URL='https://en.wikipedia.org/wiki/Exogenous']Exogenous[/URL] progesterone, such as [URL='https://en.wikipedia.org/wiki/Oral_administration']oral[/URL] progesterone, elevates allopregnanolone levels in the body with good dose-to-serum level correlations.[URL='https://en.wikipedia.org/wiki/Allopregnanolone#cite_note-pmid16406399-57'][57][/URL] Due to this, it has been suggested that oral progesterone could be described as a [URL='https://en.wikipedia.org/wiki/Prodrug']prodrug[/URL] of sorts for allopregnanolone.[URL='https://en.wikipedia.org/wiki/Allopregnanolone#cite_note-pmid16406399-57'][57][/URL] As a result, there has been some interest in using oral progesterone to treat catamenial epilepsy,[URL='https://en.wikipedia.org/wiki/Allopregnanolone#cite_note-DevinskySchachter2005-58'][58][/URL] as well as other menstrual cycle-related and neurosteroid-associated conditions. In addition to oral progesterone, oral [URL='https://en.wikipedia.org/wiki/Pregnenolone']pregnenolone[/URL] has also been found to act as a prodrug of allopregnanolone,[URL='https://en.wikipedia.org/wiki/Allopregnanolone#cite_note-pmid15763596-59'][59][/URL][URL='https://en.wikipedia.org/wiki/Allopregnanolone#cite_note-pmid21538944-60'][60][/URL][URL='https://en.wikipedia.org/wiki/Allopregnanolone#cite_note-pmid23348009-61'][61][/URL] though also of [URL='https://en.wikipedia.org/wiki/Pregnenolone_sulfate']pregnenolone sulfate[/URL].[URL='https://en.wikipedia.org/wiki/Allopregnanolone#cite_note-pmid20570588-62'][62][/URL] [COLOR=#252525]Note: TRT shuts down LH which is essential in the production of pregnenolone and progesterone.[/COLOR] [B][URL='https://www.excelmale.com/forum/showthread.php?3990-Anabolic-steroids-and-TRT-decrease-SHBG-DHEA-pregnenolone-and-progesterone-in-men']Anabolic steroids and TRT decrease SHBG, DHEA, pregnenolone and progesterone in men.[/URL][/B] [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
How Can I Increase My Allopregnanolone ?
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