Hormones and Stroke: An update on treatment and risk

madman

Super Moderator


Introduction (00:00)
Dr. Matthew Nudy (03:57)
Prof. Dominique Cadilhac (26:34)
Q&A (54:24)

  • 04:01 Hormonal effects on stroke risk include factors specific to women and may be hormonally mediated.
  • 08:01 Risk factors for cardiovascular disease include diabetes, hypertension, obesity, tobacco use, high cholesterol, age, family history, and more.
  • 10:15 Premature menopause before the age of 42 is associated with nearly double the risk of stroke.
  • 12:06 Women experiencing moderate to severe menopausal symptoms may have an increased risk of stroke.
  • 13:53 Clinical trials like the WHI showed an increased risk of stroke with hormone therapy, particularly with oral estrogen.
  • 19:01 ️ The timing hypothesis suggests that the effects of estrogen on stroke risk may vary depending on age or time since menopause.
  • 23:51 Transdermal estrogen may be safer regarding stroke risk compared to oral estrogen, but more research, especially randomized clinical trials, is needed.
    • 49:41 Movement-based mindfulness intervention is designed to reduce stress levels, blood pressure, and potentially influence blood glucose and lipid levels, benefiting stroke recovery.
    • 50:24 Digital health interventions, including mobile apps, can personalize strategies for risk factor reduction and chronic disease management, improving lifestyle behaviors for stroke prevention.
    • 51:35 The Stroke Riskometer app endorsed by the World Stroke Organization aids in primary prevention by assessing modifiable risk factors and encouraging users to seek preventative measures.
    • 52:19 ⌚ Wearable technology coupled with apps and clinician portals facilitates secondary prevention post-stroke, enabling remote monitoring, goal-setting, and intervention for better long-term outcomes.
    • 53:11 Co-designed solutions considering context and community impact are crucial for improving stroke care from prehospital to long-term management, with a focus on gender-specific treatments and routine monitoring.

 
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hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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