Highest estradiol level ever from HCG

Hi everybody,

I thought I would share some results with others of my high E2 situation.

Have been on Cypionate for years; cycling on and off at times on HCG with suspected secondary hypogonadism that began when I was around 14 (I am 40-years old now).

This year I made quite a nice discovery: that I feel better by taking only HCG. For whatever reason I could never attain good results with energy and sexual by taking testosterone alone. However with HCG that is significantly improved, but it has never lasted long and always seemed to come and go in cycles.

My dose was 100 MG of Testosterone every 10-days or so; with 500 miu of HCG aprox. 3x per week
.

With this dose my E2 became 295 pmol/L or around 80 pg/ML! That is the highest ever and exceeded when I was on clomid and felt terrible a number of years ago.

The symptoms:
significantly less energy, very low penis sensitivity, inability to get an erection even with PDE5 inhibitors.

I have always had very low, usually the lowest on the reference range when it comes to SHBG so perhaps I am more sensitive to injections then others as my free androgen index is usually 'high' off the chart despite a very modest testosterone dosage. E2 has never been out of control other then on Clomid when I started.

The good news I suppose is that I know HCG is the drug that makes my body work. The flip side is that when HCG works, it really works. Libido goes off the chart and I can get erections at times without any help from PDE5 inhibitors (something that has been impossible since I was a teenager so it is meaningful.) Also the testosterone "flex" feeling when you work out is substantial. However when E2 is high, I am sure these positive side effects of the two drugs totally dissipates and it feels like I am injecting saline or worse.

I have reduced my dose to 80 MG per week and after coming across a blood survey by valued forum Dr Justin Saya, decided to toggle my HCG to every 3rd day at 500 miu rather then EOD.

I will do another blood test is a couple weeks or so at a private clinic and report back.

Again, thanks for all those who put their inputs onto this forum and the team running the site. I have used this site countless time over the past decade for my own health benefits as information is rather scarce.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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