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Postmenopausal women who had higher testosterone to estradiol ratios had an increased risk for incident CVD, CHD and HF events, according to a study published in the Journal of the American College of Cardiology.
“Although sex hormone levels may be linked to future cardiovascular events, it is unclear what the best intervention is to modify sex hormone levels for risk reduction,”Erin D. Michos, MD, MHS, associate professor of medicine at Johns Hopkins University School of Medicine and a Cardiology Today Next Gen Innovator, said in a press release. “However, a sex hormone profile higher in male hormones may identify a woman at higher risk for cardiovascular disease who may benefit from other risk reduction strategies.”
“Several biological mechanisms may underlie the association between endogenous sex hormones and CVD and its risk factors in women,” Zhao and colleagues wrote. “Estrogens can promote vasodilation through increasing plasma concentrations of endothelium-derived relaxing factor nitric oxide and can inhibit the renin angiotensin system by reducing transcription of angiotensin-converting enzyme. In addition to its favorable effects on lipids, estrogens can also reduce blood pressure through increasing endothelial vasodilator function and modulating autonomic function. Additionally, estrogen is thought to regulate specific inflammatory markers and cytokines. By contrast, testosterone can induce vasoconstriction and increased platelet aggregation through upregulation of thromboxane.”
"Elevated testosterone to estradiol ratios increase CVD risk in postmenopausal women," Journal of the American Journal of Cardiology, 2018, https://www.healio.com/cardiology/c...ios-increase-cvd-risk-in-postmenopausal-women
“Although sex hormone levels may be linked to future cardiovascular events, it is unclear what the best intervention is to modify sex hormone levels for risk reduction,”Erin D. Michos, MD, MHS, associate professor of medicine at Johns Hopkins University School of Medicine and a Cardiology Today Next Gen Innovator, said in a press release. “However, a sex hormone profile higher in male hormones may identify a woman at higher risk for cardiovascular disease who may benefit from other risk reduction strategies.”
“Several biological mechanisms may underlie the association between endogenous sex hormones and CVD and its risk factors in women,” Zhao and colleagues wrote. “Estrogens can promote vasodilation through increasing plasma concentrations of endothelium-derived relaxing factor nitric oxide and can inhibit the renin angiotensin system by reducing transcription of angiotensin-converting enzyme. In addition to its favorable effects on lipids, estrogens can also reduce blood pressure through increasing endothelial vasodilator function and modulating autonomic function. Additionally, estrogen is thought to regulate specific inflammatory markers and cytokines. By contrast, testosterone can induce vasoconstriction and increased platelet aggregation through upregulation of thromboxane.”
"Elevated testosterone to estradiol ratios increase CVD risk in postmenopausal women," Journal of the American Journal of Cardiology, 2018, https://www.healio.com/cardiology/c...ios-increase-cvd-risk-in-postmenopausal-women
