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That is very interesting! I have done some reading on the Rho-Kinase pathway with regard to it being one of the pathways that maintain the penis in a flaccid state. I did not know Ibuprofen was an inhibitor of Rho-kinase.

Altered RHOA/ROCK activity in the penis is being studied as a potential cause of ED.

I have noticed this effect with ibuprofen as well in the past.