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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
High Iron, Low Ferritin (high-normal cbc)
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<blockquote data-quote="thedeparted" data-source="post: 78678" data-attributes="member: 13778"><p>So got my Hereditary hemochromatosis result back. Apparently I have one mutation for it, but it takes 2 for it to be significant from what my Dr told me. </p><p></p><table class='post-table class: components, width: 808' style='width: 100%'><tr><td ><p>[TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH]<br /> [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH]<br /> [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH]<br /> [TH="bgcolor: #006BA6, align: left"]FLAG[/TH]</p></td></tr><tr><td ><p>[TD="class: nameCol srchbl"]HEMOCHROMATOSIS RESULT[/TD]<br /> [TD="class: valueCol"]One Mutation detected (C282Y)[/TD]<br /> [TD="class: rangeCol"][/TD]<br /> [TD="class: flagCol"][/TD]</p></td></tr><tr><td ><p>[TD="class: srchbl, colspan: 4"]DNA MUTATION ANALYSIS<br /> RESULT: HETEROZYGOUS FOR THE C282Y MUTATION<br /> INTERPRETATION: DNA testing indicates that this<br /> individual is positive for one copy of the C282Y<br /> mutation in the HFE gene. This individual is negative<br /> for the H63D mutation. Individuals with this genotype<br /> may have elevated serum transferrin iron saturation<br /> levels. This result reduces the likelihood that this<br /> individual is affected by hereditary hemochromatosis<br /> (HH). However, it does not rule out the presence of<br /> other mutations within the HFE gene or a diagnosis of<br /> HH. The risk of this individual carrying a HFE<br /> mutation other than those tested in this assay depends<br /> greatly on family and clinical history as well as<br /> ethnicity. This assay does not test for other primary<br /> or secondary iron overload disorders. Consider genetic<br /> counseling and DNA testing for at-risk family members.<br /> <br /> <br /> Hereditary hemochromatosis (HH) is an autosomal<br /> recessive disorde<br /> r of iron metabolism that results in<br /> iron overload and potential organ failure. It is one<br /> of the most common genetic disorders in individuals of<br /> European-Caucasian ancestry, with an estimated carrier<br /> frequency of 10%. HH is caused by mutations in the HFE<br /> gene. Most individuals with HH (60-90%) are homozygous<br /> for the C282Y mutation. A smaller percentage of<br /> affected individuals are either compound heterozygous<br /> for the C282Y and H63D mutations (3%-8%), or homozygous<br /> for the H63D mutation (approximately 1%).<br /> This assay detects the two mutations in the HFE gene,<br /> C282Y (NM_000410.2: c.845G>A) and H63D (NM_000410.2: c.<br /> 187C>G), that are commonly associated with HH. The<br /> mutations are detected by multiplex-polymerase chain<br /> reaction (PCR) amplification, followed by digestion of<br /> the amplification products with the restriction enzymes<br /> Rsal and NlaIII, for the detection of the C282Y and<br /> H63D mutations respectively. Fluorescent-labeled<br /> restriction fragments are detected by ca<br /> pillary<br /> electrophoresis.<br /> This assay does not detect other mutations in the HFE<br /> gene that can cause HH. Since genetic variation and<br /> other factors can affect the accuracy of direct<br /> mutation testing, these results should be interpreted<br /> in light of clinical and familial data.[/TD]</p></td></tr></table></blockquote><p></p>
[QUOTE="thedeparted, post: 78678, member: 13778"] So got my Hereditary hemochromatosis result back. Apparently I have one mutation for it, but it takes 2 for it to be significant from what my Dr told me. [TABLE="class: components, width: 808"] [TR] [TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH] [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH] [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH] [TH="bgcolor: #006BA6, align: left"]FLAG[/TH] [/TR] [TR="class: odd"] [TD="class: nameCol srchbl"]HEMOCHROMATOSIS RESULT[/TD] [TD="class: valueCol"]One Mutation detected (C282Y)[/TD] [TD="class: rangeCol"][/TD] [TD="class: flagCol"][/TD] [/TR] [TR="class: tableRowMessage comments odd"] [TD="class: srchbl, colspan: 4"]DNA MUTATION ANALYSIS RESULT: HETEROZYGOUS FOR THE C282Y MUTATION INTERPRETATION: DNA testing indicates that this individual is positive for one copy of the C282Y mutation in the HFE gene. This individual is negative for the H63D mutation. Individuals with this genotype may have elevated serum transferrin iron saturation levels. This result reduces the likelihood that this individual is affected by hereditary hemochromatosis (HH). However, it does not rule out the presence of other mutations within the HFE gene or a diagnosis of HH. The risk of this individual carrying a HFE mutation other than those tested in this assay depends greatly on family and clinical history as well as ethnicity. This assay does not test for other primary or secondary iron overload disorders. Consider genetic counseling and DNA testing for at-risk family members. Hereditary hemochromatosis (HH) is an autosomal recessive disorde r of iron metabolism that results in iron overload and potential organ failure. It is one of the most common genetic disorders in individuals of European-Caucasian ancestry, with an estimated carrier frequency of 10%. HH is caused by mutations in the HFE gene. Most individuals with HH (60-90%) are homozygous for the C282Y mutation. A smaller percentage of affected individuals are either compound heterozygous for the C282Y and H63D mutations (3%-8%), or homozygous for the H63D mutation (approximately 1%). This assay detects the two mutations in the HFE gene, C282Y (NM_000410.2: c.845G>A) and H63D (NM_000410.2: c. 187C>G), that are commonly associated with HH. The mutations are detected by multiplex-polymerase chain reaction (PCR) amplification, followed by digestion of the amplification products with the restriction enzymes Rsal and NlaIII, for the detection of the C282Y and H63D mutations respectively. Fluorescent-labeled restriction fragments are detected by ca pillary electrophoresis. This assay does not detect other mutations in the HFE gene that can cause HH. Since genetic variation and other factors can affect the accuracy of direct mutation testing, these results should be interpreted in light of clinical and familial data.[/TD] [/TR] [/TABLE] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
High Iron, Low Ferritin (high-normal cbc)
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