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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
High estrogens / SHBG
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<blockquote data-quote="Castaneda" data-source="post: 140187" data-attributes="member: 36807"><p>You know, I slept on this one and woke up this morning feeling that I would just forego AI for now. I intuitively feel that my primary issue is high adiposity and suboptimal thyroid. I did an InBody 230 measurement in the doc's office before starting therapy. It showed lean body mass at 172.9 with a total weight of 215. That puts fat % just north of 19%. Since starting T therapy, my weight has gone up to 220 without making any changes whatsoever to diet or exercise. The first thing that came to my mind was increased water weight from estrogen, but I don't want to draw conclusions in a void like that anymore. This morning, I basically just sucked it up and said to myself, "OK, just drag yourself to lose that extra weight, widen the fasting window, and put carbs around workouts... and things will come in line".</p><p></p><p></p><p></p><p>I think your statement about SHBG and potentially low calc'd E2 are right on the money. I don't want to play Russian roulette with biology here. I don't have gynecomastia and emotions are stable. Further, my wife (who has a great body even after 3 kids) used to walk around naked at night and I'd be lucky to feel "in the mood". Now, she steps out of the shower, and I have to restrain myself to all but throw her on the bed, so let's put things into context. I'm probably just being greedy about how I "want to feel". I keep expecting I'm going to feel 20-something again, but I'm in my mid 40's.... so the gains here are probably not going to be fully realized until I drop this excess fat. That alone, will decrease aromatase. Previous labs had my sensitive E2 at 9, so I'm probably on the right track. I'm going to just ditch the AI for now and keep an eye on high-E2 warning signs. Like you said, there's a possibility I don't have enough E2 with my SHBG..... which brings me to the question.... any tips and tricks to lower SHBG? Just 10-15 points, and I'd probably feel like a million bucks.</p><p></p><p></p><p></p><p>So... thyroid. Yes. I'm using a liothyronine solution mixed with SFAs and ethanol. It's meant to be used as a topical at 8mcg / drop, but that kind of dose of straight T3 all at once would probably send me through the roof. So what I did was take 25 drops of it and mixed it in a 1 ounce glass bottle with a dropper, so that I could titrate to 1mcg per drop. </p><p></p><p>The thing is... I want to be careful with straight T3. Taking too much too long will completely tank endogenous production and TSH will plummet to next to nothing. This feels good as long as you're taking it, but if you stop for any reason, then there's a huge, potentially deadly crisis, because the body is no longer making sufficient T4. So that's why I've been going slowly with it. I called a local compounding pharmacy, and they said the lowest dose they could compound for me is 100mcg and asked why I would want anything lower. People are just shit-stupid, sometimes. Really.</p><p></p><p>The other thing about T3 is it has a short half-life when not paired with T4 (as in NDT). T4 slows uptake, whereas with T3, you have to really dose every 3-4 hours to get the same effect. There's no "take it in the morning and at night" as with NDT. That would cause a slump in the middle of the day.</p></blockquote><p></p>
[QUOTE="Castaneda, post: 140187, member: 36807"] You know, I slept on this one and woke up this morning feeling that I would just forego AI for now. I intuitively feel that my primary issue is high adiposity and suboptimal thyroid. I did an InBody 230 measurement in the doc's office before starting therapy. It showed lean body mass at 172.9 with a total weight of 215. That puts fat % just north of 19%. Since starting T therapy, my weight has gone up to 220 without making any changes whatsoever to diet or exercise. The first thing that came to my mind was increased water weight from estrogen, but I don't want to draw conclusions in a void like that anymore. This morning, I basically just sucked it up and said to myself, "OK, just drag yourself to lose that extra weight, widen the fasting window, and put carbs around workouts... and things will come in line". I think your statement about SHBG and potentially low calc'd E2 are right on the money. I don't want to play Russian roulette with biology here. I don't have gynecomastia and emotions are stable. Further, my wife (who has a great body even after 3 kids) used to walk around naked at night and I'd be lucky to feel "in the mood". Now, she steps out of the shower, and I have to restrain myself to all but throw her on the bed, so let's put things into context. I'm probably just being greedy about how I "want to feel". I keep expecting I'm going to feel 20-something again, but I'm in my mid 40's.... so the gains here are probably not going to be fully realized until I drop this excess fat. That alone, will decrease aromatase. Previous labs had my sensitive E2 at 9, so I'm probably on the right track. I'm going to just ditch the AI for now and keep an eye on high-E2 warning signs. Like you said, there's a possibility I don't have enough E2 with my SHBG..... which brings me to the question.... any tips and tricks to lower SHBG? Just 10-15 points, and I'd probably feel like a million bucks. So... thyroid. Yes. I'm using a liothyronine solution mixed with SFAs and ethanol. It's meant to be used as a topical at 8mcg / drop, but that kind of dose of straight T3 all at once would probably send me through the roof. So what I did was take 25 drops of it and mixed it in a 1 ounce glass bottle with a dropper, so that I could titrate to 1mcg per drop. The thing is... I want to be careful with straight T3. Taking too much too long will completely tank endogenous production and TSH will plummet to next to nothing. This feels good as long as you're taking it, but if you stop for any reason, then there's a huge, potentially deadly crisis, because the body is no longer making sufficient T4. So that's why I've been going slowly with it. I called a local compounding pharmacy, and they said the lowest dose they could compound for me is 100mcg and asked why I would want anything lower. People are just shit-stupid, sometimes. Really. The other thing about T3 is it has a short half-life when not paired with T4 (as in NDT). T4 slows uptake, whereas with T3, you have to really dose every 3-4 hours to get the same effect. There's no "take it in the morning and at night" as with NDT. That would cause a slump in the middle of the day. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
High estrogens / SHBG
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