So a few things. High SHBG will bind to E2 just like it does testosterone and DHT. It won’t bind to test and dht only, and let E2 float around unbound. So you have a more likely chance of your E2 not being high enough, rather than too high. 0.5mg of Arimidex twice a week is a very high dose. That is going to tank your E2, I can guarantee it. That dose has made my E2 go from 71, to single digits. So whatever you do, don’t take that high of a dose. I wouldn’t recommend an ai with your E2 and SHBG level, but if you do want to try it, start off with 0.125mg once per week, twice per week max. I promise you 0.5mg 2x/ week is going to be a horrible experience for you. Not exaggerating.
I’m trying to figure out why you felt so great at the beginning of using the cream, and then things got worse. The first thing that comes to everyone’s mind is obv that E2 accumulated and ruined everything. That might still be a possibility, but I’m not sure if that’s the culprit. Could it be that at the beginning you had some natural levels still going? Probably not though. You had just come off using testosterone cypionate. So that’s probably not it. I would maybe try increasing the dose to see if that helps. Other than that, all I can think of is maybe your E2 might need to come down a tiny tiny bit. Or maybe it needs to go up slightly. It’s hard to tell. Sometimes guys do well with their E2 around where their SHBG is. But all I know, is that if you do try to lower E2, start off with around 0.125mg/ week, to 0.125mg 2x/ week, or things are going to get even worse.
Now with thyroid, you’re absolutely on the right track. You need just straight T3 to lower RT3. Anything with T4 is going to usually make things worse. So I’m just wondering about that T3 tincture. You sure that’s something that’s been known to be effective? Why not just use the standard pharmaceutical or compounded T3 that we know works most of the time? Maybe you need to up your T3 dose. I’ve heard that you need to continue upping your dose pretty frequently, until you reach your optimal dose. If you stay at one dose for too long, the positive effects can disappear. You’re taking 12mcg of T3 right now. I’ve heard the optimal dosage of dessicated thyroid is usually 1-3 grains. Each grain contains 9mcg of T3. So usually the optimal dose of T3 people end up getting is about 9-27mcg. You’re on 12mcg, so maybe you just need to up your dose.
