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Please help me understand where I am off base. I happen to be a clinician, so while my understanding may not be optimal, I've looked at enough labs (both my own and others) to see patterns.


The estradiol listed above is the (inaccurate) Roche ECLIA method that Life Extension uses. I have followed up with "sensitive assays" (LabCorp and Quest), and they all show numbers below 10. Tendonitis and muscle pain are some of the symptoms of low estradiol -- not to go off on a tangent, but here's a good introduction to this subject:


https://www.sciencedirect.com/science/article/pii/S0960076017301590


I have gotten into this problem by using DIM, aromatase inhibitors, and lately -- androsterone. It lowers my already low estradiol, causing the aforementioned issues.


So let's make this conversation useful, if possible, and guide each other. I'm not holding onto any dogma here. I just haven't found anyone that understands these pathways very well and is able to navigate this problem. Yes, I get it: using TRT is going to overcome the high SHBG and resolve the problems of functionally low T. It's low hanging fruit. As I have mentioned above, I want to explore other options before making that leap.


If none are available, simply state so. I'm open to ideas one way or the other.


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