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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
High estrogens / SHBG
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<blockquote data-quote="Castaneda" data-source="post: 130478" data-attributes="member: 36807"><p>Thank you for the input.</p><p></p><p>My apologies if I wasn't clear about it, but I did measure DHEA-S (blood serum) while taking absolutely nothing, and it came out to 186.6 ug/dL (102.6-416.3), near the bottom of the range. The 2486 shown in the graphic is from a 24-hour urine metabolite test (Rhein labs). It has different ranges than blood serum. While doing the Rhein, I was on 30mg of Pregnenolone and **no DHEA**, so my interpretation was that Pregnenolone was converting to DHEA. This makes sense, seeing that the cortisol / cortisone were low end of range. If cortisol were high, then there would be less 17-OH-Pregnenolone available for DHEA production.</p><p></p><p>My hesitation with starting TRT is because my total testosterone still appears to be salvageable. I don't want to shut-down endogenous production if there is the possibility that I can resolve the estrogen imbalance problem. As a matter of fact, I have had windows of high libido and drive using the DHEA / Pregnenolone / Androsterone combination on the scrotum, but this estrone problem is always stepping in.</p><p></p><p>Silently, I know there is no way around this without targeted gene therapy or other medications which haven't been developed yet. The majority of interventions out there are still quite primitive. I actually work with a lab that performs peptide research, so I can say there are a lot of people looking at this problem. But until that goes primetime, I have to pull all the shots before jumping off a cliff with TRT. I am not comfortable with the vulnerability of being in a situation where, if ever the androgen source dries up (via FDA regulations or God knows what else), I don't want to be left with the T levels of 13-year old girl. Call me paranoid.</p></blockquote><p></p>
[QUOTE="Castaneda, post: 130478, member: 36807"] Thank you for the input. My apologies if I wasn't clear about it, but I did measure DHEA-S (blood serum) while taking absolutely nothing, and it came out to 186.6 ug/dL (102.6-416.3), near the bottom of the range. The 2486 shown in the graphic is from a 24-hour urine metabolite test (Rhein labs). It has different ranges than blood serum. While doing the Rhein, I was on 30mg of Pregnenolone and **no DHEA**, so my interpretation was that Pregnenolone was converting to DHEA. This makes sense, seeing that the cortisol / cortisone were low end of range. If cortisol were high, then there would be less 17-OH-Pregnenolone available for DHEA production. My hesitation with starting TRT is because my total testosterone still appears to be salvageable. I don't want to shut-down endogenous production if there is the possibility that I can resolve the estrogen imbalance problem. As a matter of fact, I have had windows of high libido and drive using the DHEA / Pregnenolone / Androsterone combination on the scrotum, but this estrone problem is always stepping in. Silently, I know there is no way around this without targeted gene therapy or other medications which haven't been developed yet. The majority of interventions out there are still quite primitive. I actually work with a lab that performs peptide research, so I can say there are a lot of people looking at this problem. But until that goes primetime, I have to pull all the shots before jumping off a cliff with TRT. I am not comfortable with the vulnerability of being in a situation where, if ever the androgen source dries up (via FDA regulations or God knows what else), I don't want to be left with the T levels of 13-year old girl. Call me paranoid. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
High estrogens / SHBG
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