High E2 with Only Moderately High T - What are the Options?

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RoneTone

Member
Hey guys,
I just received an E2 result of 72pg/mL on a reference range of 7-42pg/mL. This is an ECLIA test. I do not have access to a sensitive test. I’m hoping I can get some advice. Here’s my situation. Started TRT in Jan with baselines of (same ECLIA tests and lab for everything):

· Test: 310
· E2: 27
· All other labs like BW, lipids, etc., thyroid looked good except very high LH and FSH levels and elevated eosinophils (I have weakened immune system from the cancer I had). That is normal however as I had testicular cancer and had one of the boys removed.

6 weeks in I got tested and after running 105mg test Cyp E03 SQ with 150iu of HCG MWF

· Test: 525
· E2: 31

I felt pretty good at this point, but I never really got that ‘I feel great’ that so many guys seem to get so I decided to up my dose to 116mg E03 and stick with the same HCG. I didn’t get tested for about 3 ½ months until yesterday. I’ve been feeling pretty good, I’ve added over 15lb of muscle since Jan and I’m strong in the gym, but I have a bit of facial bloat and my erections/libido is worse than the 6 week mark and before starting TRT.

I also added in 1.5iu of HGH 6 days a week as prescribed by a local doctor in an attempt to boost my immune system (I get autoimmune like conditions after the cancer). This, after a month of use, has added a sense of well-being and I sleep really well now, but I can’t say it’s helped with erections.

The latest test with 116mg E03, 150iu HCG MWF, and 1.5iu HGH 6 days a week

· Test: 721
· E2: 72

I’m waiting for my SHBG result that will come next week. These tests are hard to do and expensive where I am.

The rest of my blood work looks good. No issue with Hematocrit or bad lipids (my profile did get about 10-15% worse after starting TRT but overall is still in good range).

My question to those with experience: Are there only 2 options to get this E2 back into 30s? Take an AI or reduce the dose? I was hoping to get my T around 700. I have that now but high E2 came along with it. Any other suggestions I could try to keep my T around 700 without having to use an AI? I really want to get back to having better erection quality. I can get erections now but it’s not easy to maintain them and the sensitivity during sex is not as good as it was at the 6 week or before TRT mark. That I hear is a symptom of high E2 as is my puffy morning face.

Also, my research tells me that HGH cannot raise E2, but has anyone had experiences that say otherwise?

And – is 6 weeks really enough time to see E2 stabilize? For example, if I would have continued along at 105mg could my E2 have floated up?

Thanks in advance - love this site!
 
Defy Medical TRT clinic doctor

ERO

Member
The regular E2 test may (It can vary) show 20 or more points higher than the far more accurate sensitive E2 test, so its is hard to speculate on what your true E2 level may be. Has your doctor ruled out a low dose of AI for you?
 

RoneTone

Member
The regular E2 test may (It can vary) show 20 or more points higher than the far more accurate sensitive E2 test, so its is hard to speculate on what your true E2 level may be. Has your doctor ruled out a low dose of AI for you?

I agree concerning the test, but it's all I have here, unfortunately.

My doc hasn't done that, it's more of something that I want to avoid.

Maybe I'll just go back to 45mg E02 with 150iu HCG MWF and drop the HGH. Then retest in a month to see. I want results now but I'd rather not get going on a AI.

If I were to get going on an AI, what is the amount I would take with just 100mg of test a week?
 

ERO

Member
A very small amount to start would be my recommendation as it doesn't take much to tank your E2 and then it takes a long time to recover. Something like 1/4 mg or 1/8 mg twice a week. It's not really possible to cut the 1mg pills into 8ths, (or at least I cant do it) so you may want to get it from a compounding pharmacy if you can.
 

RoneTone

Member
Ero, thanks for the advice.

I think I'm going to lower my dose to 40mg E03, take some DIM I just picked up and drop the HCG for 2-3 weeks. Then I'll get tested again to reestablish a baseline. I'm hoping to get back to around 30 without an AI.
 
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