High E2. Not sure I care.

[mjb]

I am having great results after switching from clomiphene to testosterone/hCG. Estradiol is elevated, but I am feeling good. Do I just hold the course if things are going well, even though E2 is 72.8?

Protocol for one month prior to labs was 50mg test cypionate and 250iu hCG every 2 days. I was doing Q3.5 days with higher equivalent dosages for 8 weeks before that, but having bad injection site reactions and changed to canola oil and more frequent dosing.

LABS
Pre-Clomiphene
Clomiphene/Anastrozole/DHEA
Testosterone/HCG/DHEA

Testosterone, Serum 305-->788-->886-->1105-->1084-->934-->1039

Free Testosterone(Direct) 5-->15.7-->16.3 -->19.4-->16.3-->20.6-->26.4

DHEA-Sulfate 106-->291.9-->253-->293.6-->600.5-->453.1

Estradiol, Sensitive 16.5 -->29.2 -->20.9-->29.7-->29.4-->28.5-->72.8

SHBG 42-->46.9-->44-->68-->63-->61.2-->38.4

T:E ratio 18.5 -->26.8-->41.43-->37-->36.8-->32.77-->14.3

Free T : Total T 1.6%-->2%-->1.8%-->1.76%-->1.5%-->2.2%-->2.5%

 

[FeelingLost]

It is very interesting that boosting your natural T did not raise your E2 but inject it to about the same lvl and all hell breaks loose. If you are not feeling this high E2 you probably shouldn't worry about it hell it could be a lab error they do that more than one would hope. If you end up losing your libido or develop ED or start putting on water weight, or become extra bitchy you will know the cause.

 

[Nashtide]

I am having great results after switching from clomiphene to testosterone/hCG. Estradiol is elevated, but I am feeling good. Do I just hold the course if things are going well, even though E2 is 72.8?

Protocol for one month prior to labs was 50mg test cypionate and 250iu hCG every 2 days. I was doing Q3.5 days with higher equivalent dosages for 8 weeks before that, but having bad injection site reactions and changed to canola oil and more frequent dosing.

LABS
Pre-Clomiphene
Clomiphene/Anastrozole/DHEA
Testosterone/HCG/DHEA

Testosterone, Serum 305-->788-->886-->1105-->1084-->934-->1039

Free Testosterone(Direct) 5-->15.7-->16.3 -->19.4-->16.3-->20.6-->26.4

DHEA-Sulfate 106-->291.9-->253-->293.6-->600.5-->453.1

Estradiol, Sensitive 16.5 -->29.2 -->20.9-->29.7-->29.4-->28.5-->72.8

SHBG 42-->46.9-->44-->68-->63-->61.2-->38.4

T:E ratio 18.5 -->26.8-->41.43-->37-->36.8-->32.77-->14.3

Free T : Total T 1.6%-->2%-->1.8%-->1.76%-->1.5%-->2.2%-->2.5%

hard to argue with how you are feeling, but don't be too surprised if that all changes sometime soon.

 

[CoastWatcher]

It's easier, in most cases, to reduce estradiol rather than work to raise it after it has been crashed. So...intervention of a subtle nature, if - probably when - it's called for. But, by all means, symptoms first.

 

[HealthMan]

At these levels I would be worried about your long term prostate health.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1477605/

 

[ratbag]

and of course 1 month is too early to get your system stabilised on testosterone injections w/HCG. You'll probably be able to reduce your dose once you get results after 40 days of being on testosterone / HCG injections.

 

[mjb]

and of course 1 month is too early to get your system stabilised on testosterone injections w/HCG. You'll probably be able to reduce your dose once you get results after 40 days of being on testosterone / HCG injections.

Just to clarify, I was injecting test for ~90 days before the labs. The last month of which I switched to EOD injections from Q 3.5d.

 

[mjb]

It is very interesting that boosting your natural T did not raise your E2 but inject it to about the same lvl and all hell breaks loose. If you are not feeling this high E2 you probably shouldn't worry about it hell it could be a lab error they do that more than one would hope. If you end up losing your libido or develop ED or start putting on water weight, or become extra bitchy you will know the cause.

Good points. I wonder if it was a lab error. I feel great and have no typical high E symptoms. I might even be less cranky than usual, sex drive is so high it's almost too much, and body comp. has improved quite a bit.

 

[ratbag]

any change in protocol with testosterone means your body needs 40 days to stabilise. Any labs before that 40 day period will change again.

 

[mjb]

hard to argue with how you are feeling, but don't be too surprised if that all changes sometime soon.

Could be. I was expecting some sort of a leveling out period with the change to injections, like I had with the clomid, but have been feeling very even. I have some anastrazole sitting on the shelf just in case I start getting the urge to shop for shoes though.

 

[mjb]

It's easier, in most cases, to reduce estradiol rather than work to raise it after it has been crashed. So...intervention of a subtle nature, if - probably when - it's called for. But, by all means, symptoms first.

Well put. I will be sure to go slow with any changes.

Anyone have thoughts on what to change first, when the time comes? Less test, less hCG, etc.? I know a subset of guys don't do well with hCG.

 

[Nashtide]

Could be. I was expecting some sort of a leveling out period with the change to injections, like I had with the clomid, but have been feeling very even. I have some anastrazole sitting on the shelf just in case I start getting the urge to shop for shoes though.

Remember, women notice a gentlemans shoes, so don't underestimate the value of shoe shopping! In all seriousness, if your E2 is really that high, it's a really good chance that you'll have symptoms sooner than later. Best of luck.

 

[mjb]

any change in protocol with testosterone means your body needs 40 days to stabilise. Any labs before that 40 day period will change again.

Ah, I see. Thanks. Sounds like this discussion may be a little premature then.

 

[lowe2sucks]

whats wrong with urge for buying shoes lol

 

[Vince Carter]

Good points. I wonder if it was a lab error. I feel great and have no typical high E symptoms. I might even be less cranky than usual, sex drive is so high it's almost too much, and body comp. has improved quite a bit.

Most likely explanation for one out of bounds test like this. I would retest and verify before doing anything.

 

[OMI100]

If you have seen this article go ahead and read....:
GREAT article onE2 – A MUST READ
http://www.peaktestosterone.com/Hdr_Estrogen.aspx
********************************

 

[mjb]

I rested after another 5 weeks on my EOD protocol (9 weeks total) and numbers are all down. E2 is still high, but feeling pretty good.

Total T 861 (264-916)
Free T 20.9 (6.8-21.5)
E2 57.7 (8-35)

Trying to decide if I hold steady and retest in a few months or try some tweaks to see how it feels.

 

[Nashtide]

Is there any concern that high E2 may have no negative symptoms but could have negative long term health effects?

 

[MarkM]

This interview by Nelson with Dr. Ramasamy regarding estradiol management is very good. I personally found it very informative and it may change some individuals opinions on estradiol. I recommend viewing it when you have time.

https://www.excelmale.com/forum/thr...-urology-professor-dr-ranjith-ramasamy.10539/

 

[mjb]

This interview by Nelson with Dr. Ramasamy regarding estradiol management is very good. I personally found it very informative and it may change some individuals opinions on estradiol. I recommend viewing it when you have time.

https://www.excelmale.com/forum/thr...-urology-professor-dr-ranjith-ramasamy.10539/

Thanks for linking to this. Very interesting. Dr. Ramasamy doesnt seem to be too worried about treating E2 until it's over 60. And Dr. Saya seems okay with 45-50.

I will likely keep testing and see where mine settles.