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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
HELP PLEASE. Why is my pregnenolone so low, test is low, but DHEA and Free test through the roof.
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<blockquote data-quote="Nelson Vergel" data-source="post: 80923" data-attributes="member: 3"><p>Labcorp uses liquid chromatography to measure pregnenolone. It is not cheap </p><p></p><p><a href="https://www.discountedlabs.com/pregnenolone" target="_blank">https://www.discountedlabs.com/pregnenolone</a></p><p></p><p>What is your cholesterol? What oral supplements are you taking? </p><p></p><p>• Pregnenolone is produced from cholesterol.</p><p>The conversion of cholesterol to steroids occurs in the internal mitochondrial membrane.</p><p>•How does cholesterol get from the external membrane to the internal membrane? Answer: Steroidogenic acute regulatory protein (StAR), which transports cholesterol into the mitochondria, moving it from the outer membrane to the inner membrane.</p><p></p><p>[ATTACH]4054[/ATTACH]</p><p></p><p></p><p>StAR is a mitochondrial protein that is rapidly synthesized in response to stimulation of the cell to produce steroid. Hormones that stimulate its production depend on the cell type and include luteinizing hormone (LH), ACTH and angiotensin II, so low levels of any of those hormones may affect StAR activity. Blocking LH with TRT can shut down StAR.</p><p></p><p>Alcohol can decrease StAR activity (at least in animal models).</p><p></p><p>There are no agreed upon ranges of "normal pregnenolone" levels in men. 11-50 ng/dL seems to be a common range I see around.</p><p></p><p><a href="https://www.discountedlabs.com/blog/post/pregnenolone-what-you-need-to-know/" target="_blank">More information on pregnenolone</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 80923, member: 3"] Labcorp uses liquid chromatography to measure pregnenolone. It is not cheap [URL]https://www.discountedlabs.com/pregnenolone[/URL] What is your cholesterol? What oral supplements are you taking? • Pregnenolone is produced from cholesterol. The conversion of cholesterol to steroids occurs in the internal mitochondrial membrane. •How does cholesterol get from the external membrane to the internal membrane? Answer: Steroidogenic acute regulatory protein (StAR), which transports cholesterol into the mitochondria, moving it from the outer membrane to the inner membrane. [ATTACH=CONFIG]4054[/ATTACH] StAR is a mitochondrial protein that is rapidly synthesized in response to stimulation of the cell to produce steroid. Hormones that stimulate its production depend on the cell type and include luteinizing hormone (LH), ACTH and angiotensin II, so low levels of any of those hormones may affect StAR activity. Blocking LH with TRT can shut down StAR. Alcohol can decrease StAR activity (at least in animal models). There are no agreed upon ranges of "normal pregnenolone" levels in men. 11-50 ng/dL seems to be a common range I see around. [URL="https://www.discountedlabs.com/blog/post/pregnenolone-what-you-need-to-know/"]More information on pregnenolone[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
HELP PLEASE. Why is my pregnenolone so low, test is low, but DHEA and Free test through the roof.
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