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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Help me dial in my protocol Nebido
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<blockquote data-quote="Cataceous" data-source="post: 176548" data-attributes="member: 38109"><p>With those numbers I would go with a lower dose. Assume a rough proportionality between serum testosterone and dose. There's not firm agreement on target levels, but I'd aim for total testosterone of 28-30 nMol/L, which still puts calculated free testosterone in the upper part of the healthy normal range. Although top-of-range and higher levels may be better for body composition and athleticism, there's speculation that other parameters—libido, motivation, mood, lipids, etc.—may not be as good if you're well over your optimum natural level. The proportionality suggests a new weekly dose of 34 IU. The problem with starting high and lowering the dose is that you may initially have hypogonadal symptoms. Anecdotal reports suggest that if you can get through this then you may have better results. Nebido makes this challenging because the process is so much longer.</p><p></p><p>Potentially you can make things go a little faster by skipping some doses, which is the converse of preloading when going up with the dose. There's guesswork involved because you must assume a particular half-life for your serum testosterone. For example, let's say you want to drop from 47 to 30 nMol/L, and assume a half-life of 21 days. In theory this takes two weeks, which means skipping two doses before resuming at the new lower dose rate.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 176548, member: 38109"] With those numbers I would go with a lower dose. Assume a rough proportionality between serum testosterone and dose. There's not firm agreement on target levels, but I'd aim for total testosterone of 28-30 nMol/L, which still puts calculated free testosterone in the upper part of the healthy normal range. Although top-of-range and higher levels may be better for body composition and athleticism, there's speculation that other parameters—libido, motivation, mood, lipids, etc.—may not be as good if you're well over your optimum natural level. The proportionality suggests a new weekly dose of 34 IU. The problem with starting high and lowering the dose is that you may initially have hypogonadal symptoms. Anecdotal reports suggest that if you can get through this then you may have better results. Nebido makes this challenging because the process is so much longer. Potentially you can make things go a little faster by skipping some doses, which is the converse of preloading when going up with the dose. There's guesswork involved because you must assume a particular half-life for your serum testosterone. For example, let's say you want to drop from 47 to 30 nMol/L, and assume a half-life of 21 days. In theory this takes two weeks, which means skipping two doses before resuming at the new lower dose rate. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Help me dial in my protocol Nebido
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