Helen Mayberg on Pioneering Brain Stimulation and the Future of Depression Treatment

madman

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Helen Mayberg at the BrainMind Special Forum in Neuromodulation/BCI/AI, interviewed by BrainMind member Jane Roskams.

Helen Mayberg is the Director of the Nash Family Center at Mount Sinai for Advanced Circuit Therapeutic, Professor of Neurology, Psychiatry, Neuroscience and Neurosurgery.

The discussion delves into Mayberg’s groundbreaking work, especially her early use of advanced brain imaging to transition DBS from treating Parkinson's disease to addressing treatment-resistant depression. Mayberg reflects on the evolution of brain imaging technology, noting how it enabled precise hypotheses and improved DBS outcomes. She highlights the iterative nature of the field, emphasizing how integrating AI and signal processing has advanced understanding of brain responses to DBS. The conversation also explores the ethical dimensions of brain stimulation, the challenge of distinguishing effective treatments from hype, and the need for ongoing innovation while managing expectations. Mayberg's insights underscore the importance of balancing technological advancements with practical, patient-centered approaches in the evolving landscape of neurology and psychiatry.
 

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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