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Heart Rate Variability
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<blockquote data-quote="Nelson Vergel" data-source="post: 247573" data-attributes="member: 3"><p>According to multiple sources, beta-blockers have been shown to increase heart rate variability (HRV) in patients with heart failure and other conditions [<a href="https://pubmed.ncbi.nlm.nih.gov/11399339/" target="_blank">1</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/8176095/" target="_blank">2</a>, <a href="https://www.quora.com/How-do-beta-blockers-affect-heart-rate-variability?share=1" target="_blank">3</a>, <a href="https://www.researchgate.net/post/How_much_do_Betablockers_effect_heart_rate_variability_in_two_groups_being_compared_following_autonomic_regulation_vagotomy_ablation_etc" target="_blank">4</a>, <a href="https://www.sciencedirect.com/science/article/pii/0735109794903794" target="_blank">5</a>]. Beta-blockers slow down the heart rate by blocking the effects of the hormone epinephrine (adrenaline), causing the heart to beat more slowly and with less force [<a href="https://www.health.harvard.edu/heart-health/target-heart-rate-on-a-beta-blocker" target="_blank">10</a>]. This reduction in heart rate is thought to allow for greater variability in the time between heartbeats, leading to an increase in HRV [<a href="https://www.quora.com/How-do-beta-blockers-affect-heart-rate-variability?share=1" target="_blank">3</a>]. However, it should be noted that the effect of beta-blockers on HRV may vary depending on the patient's condition and the specific medication used [<a href="https://pubmed.ncbi.nlm.nih.gov/11399339/" target="_blank">1</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/8176095/" target="_blank">2</a>].</p><p></p><p></p><p>Nebivolol is considered a unique beta-blocker due to its ability to improve nitric oxide (NO) bioavailability and release, leading to better heart rate variability (HRV) and endothelial function compared to other beta-blockers [<a href="https://pubmed.ncbi.nlm.nih.gov/17326335/" target="_blank">1</a>]. In contrast to other beta-blockers, nebivolol does not inhibit the increase in heart rate typically seen with exercise, allowing for improved HRV and autonomic function in patients with heart failure [<a href="https://pubmed.ncbi.nlm.nih.gov/17326335/" target="_blank">1</a>]. Additionally, nebivolol is shown to have an effect on small muscular arteries, increasing pulse pressure amplification and reducing wave reflection, possibly due to increased NO levels [<a href="https://academic.oup.com/ajh/article/21/6/663/169987" target="_blank">4</a>]. Nebivolol has been demonstrated to reduce heart rate and increase ejection fraction, decrease left ventricular end-diastolic pressure, pulmonary capillary pressure, and peripheral vascular resistance in patients with Class I-II heart failure patients with an ejection fraction lower than 24% [<a href="https://www.escardio.org/Journals/E-Journal-of-Cardiology-Practice/Volume-5/Preferred-beta-blockers-for-the-treatment-of-heart-failure-Title-Preferred-be" target="_blank">8</a>]. Overall, nebivolol may be a better beta-blocker to improve HRV due to its unique NO-mediated effects and lack of inhibition of exercise-induced heart rate increase.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 247573, member: 3"] According to multiple sources, beta-blockers have been shown to increase heart rate variability (HRV) in patients with heart failure and other conditions [[URL='https://pubmed.ncbi.nlm.nih.gov/11399339/']1[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/8176095/']2[/URL], [URL='https://www.quora.com/How-do-beta-blockers-affect-heart-rate-variability?share=1']3[/URL], [URL='https://www.researchgate.net/post/How_much_do_Betablockers_effect_heart_rate_variability_in_two_groups_being_compared_following_autonomic_regulation_vagotomy_ablation_etc']4[/URL], [URL='https://www.sciencedirect.com/science/article/pii/0735109794903794']5[/URL]]. Beta-blockers slow down the heart rate by blocking the effects of the hormone epinephrine (adrenaline), causing the heart to beat more slowly and with less force [[URL='https://www.health.harvard.edu/heart-health/target-heart-rate-on-a-beta-blocker']10[/URL]]. This reduction in heart rate is thought to allow for greater variability in the time between heartbeats, leading to an increase in HRV [[URL='https://www.quora.com/How-do-beta-blockers-affect-heart-rate-variability?share=1']3[/URL]]. However, it should be noted that the effect of beta-blockers on HRV may vary depending on the patient's condition and the specific medication used [[URL='https://pubmed.ncbi.nlm.nih.gov/11399339/']1[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/8176095/']2[/URL]]. Nebivolol is considered a unique beta-blocker due to its ability to improve nitric oxide (NO) bioavailability and release, leading to better heart rate variability (HRV) and endothelial function compared to other beta-blockers [[URL='https://pubmed.ncbi.nlm.nih.gov/17326335/']1[/URL]]. In contrast to other beta-blockers, nebivolol does not inhibit the increase in heart rate typically seen with exercise, allowing for improved HRV and autonomic function in patients with heart failure [[URL='https://pubmed.ncbi.nlm.nih.gov/17326335/']1[/URL]]. Additionally, nebivolol is shown to have an effect on small muscular arteries, increasing pulse pressure amplification and reducing wave reflection, possibly due to increased NO levels [[URL='https://academic.oup.com/ajh/article/21/6/663/169987']4[/URL]]. Nebivolol has been demonstrated to reduce heart rate and increase ejection fraction, decrease left ventricular end-diastolic pressure, pulmonary capillary pressure, and peripheral vascular resistance in patients with Class I-II heart failure patients with an ejection fraction lower than 24% [[URL='https://www.escardio.org/Journals/E-Journal-of-Cardiology-Practice/Volume-5/Preferred-beta-blockers-for-the-treatment-of-heart-failure-Title-Preferred-be']8[/URL]]. Overall, nebivolol may be a better beta-blocker to improve HRV due to its unique NO-mediated effects and lack of inhibition of exercise-induced heart rate increase. [/QUOTE]
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