HCG and Nipple Itchiness

Airborne Warrior

Active Member
Does anyone find that within a few hours of an HCG injection they can feel an itching in their nipples? I'm currently administering 2 x 50mg of test E and 2 x 300IU of HCG weekly. I never get itchy nipples after my sub q test injection, just the HCG. I haven't actually got gyno but always get itchy nipples after injection.

I'm assuming the HCG is trying to raise my E2 much more than the test E is. Last test on E2 was 52.7 pmol/L well within range (0 pmol/L - 191.99 pmol/L).
 
Sensitive nipples occurs in the vast majority of men who undertake TRT. Men need the sensitive, LC, MS/MS, estradiol test.
 
HCG is pretty well known to stimulate aromatase in the testes and that may be what you're getting, an E bump. You can cut the HCG dose in half say 150iu E3.5D and see if that resolves, smaller shots EOD like 150iu EOD, something like that.
 
As both of my friends, Vince and Vince Carter, have mentioned, you're dealing with something that is unlikely to be a serious challenge to your TRT protocol. VC is right - adjusting your HCG dose/schedule may bring relief.
 

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⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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