Have you worked with highly complex data and people and got Parkinsons?

[Vince]

Background​

The etiology of Parkinson's disease (PD) remains unclear, and environmental risk-factors such as occupation have attracted interest.

Objective​

The goal was to investigate occupational complexity in relation to PD.

Methods​

We conducted a population-based cohort study based on the Swedish Twin Registry that included 28,778 twins born between 1886 and 1950. We identified 433 PD cases during the study period. Data on occupation were collected from either the 1970 or 1980 Swedish census, and occupational complexity was assessed via a job exposure matrix. Cox proportional hazard regression analyses with age as the underlying time scale were used to assess PD risk as a function of the three domains of occupational complexity: data, people, and things. Sex and smoking were included as covariates. Analyses stratified by twin pair were conducted to test for confounding by familial factors.

Results​

High occupational complexity with data and people was associated with increased risk overall (Hazard Ratio

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 = 1.07, 95% confidence interval [CI] 1.02–1.14, and HR = 1.10, 95% CI 1.01–1.21, respectively), and in men (HR = 1.08, 95% CI 1.01–1.16, and HR = 1.15, 95% CI 1.03–1.28, respectively). Complexity with things was not associated with risk of PD. When the analyses were stratified by twin pair, the HRs for occupational complexity with data and people were attenuated in men.

Conclusions​

High complexity of work with data and people is related to increased risk of PD, particularly in men. The attenuation of risk observed in the twin pair-stratified analyses suggests that the association may partly be explained by familial factors, such as inherited traits contributing to occupational selection or other factors shared by twins.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157797/

 

[Vince]

Occupational stress and risk for Parkinson's disease: A nationwide cohort study​

In conclusion, our findings suggest that occupational stress is associated with PD risk such that having a high‐demand occupation is a risk factor, and low control is protective. Thus, the meaning of job control and strain may need to be reconsidered in the context of PD. To better understand the relationship between occupational stress and PD risk, future studies may consider other models of occupational stress to elucidate whether occupational stress only is a risk factor for PD or if there are also aspects of stress that may be protective.

Occupational stress and risk for Parkinson's disease: A nationwide cohort study

Background: Stress has been suggested as a contributing factor in the etiology of Parkinson's Disease (PD), but epidemiological evidence is sparse. Objective: The objective of this study was to explore the association between occupational stress according ...

www.ncbi.nlm.nih.gov