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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Has anyone tried trestolone acetate? About to start my experiment
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<blockquote data-quote="Nelson Vergel" data-source="post: 8439" data-attributes="member: 3"><p>Sorry for taking a while to reply. We are getting bombarded lately!</p><p></p><p>I have never tried it since it is not available in the US or Mexico. It has been researched in the past 15 years as a male contraceptive.</p><p></p><p>Here is a good summary:</p><p></p><p><em>7<em><img src="https://www.nature.com/__chars/alpha/black/ital/base/glyph.gif" class="bbImage" alt="" data-url="https://www.nature.com/__chars/alpha/black/ital/base/glyph.gif" style="" /></em>-methyl-19-nortestosterone (MENT) (Also known as trestolone acetate).</em> This compound is about 10 times more potent than T in terms of anabolic activities and gonadotropin suppression, is not bound by SHBG in circulation, is not a substrate for 5<em><img src="https://www.nature.com/__chars/alpha/black/ital/base/glyph.gif" class="bbImage" alt="" data-url="https://www.nature.com/__chars/alpha/black/ital/base/glyph.gif" style="" /></em>-reductase, and has a relatively low potency for stimulation of prostate growth: approximately four times less than that of T.[SUP]<a href="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib94" target="_blank">94</a>, <a href="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib95" target="_blank">95</a>[/SUP]MENT is aromatizable to 7<em><img src="https://www.nature.com/__chars/alpha/black/ital/base/glyph.gif" class="bbImage" alt="" data-url="https://www.nature.com/__chars/alpha/black/ital/base/glyph.gif" style="" /></em>-methyl estradiol, which may confer beneficial tissue effects via the estrogen receptor.</p><p></p><p>In a randomized crossover trial involving hypogonadal men from two disparate societies (Edinburgh and Hong Kong), patients were allocated to treatment with two MENT acetate 115 mg upper-arm implants for 6 weeks and two i.m. injections of TE 200 mg at 3-week intervals. Compared with a 6-week androgen washout period, both MENT and i.m. TE significantly enhanced sexual function, with no between-group differences.[SUP]<a href="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib94" target="_blank">94</a></p><p>[/SUP]</p><p>Although the physiologic benefits of TRT on erectile function as assessed objectively by RigiScan[SUP]®[/SUP] (Timm Medical Systems, Eden Prairie, MN, USA) were significant across treatment centers,[SUP]<a href="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib94" target="_blank">94</a>[/SUP] other sexual effects were less robust. Both MENT and i.m. TE significantly enhanced self-rated interest in sex, masturbation, sexual intercourse, and overall sexual activity in Scottish, but not Chinese, men. These findings reflect the cultural context and specificity of certain sexual outcome measures.</p><p></p><p>Similar trends were observed with regard to TRT effects on mood: significant increases in self-reported cheerfulness and energy level, coupled with significant decreases in lethargy, depression, and irritability in Scottish, but not Chinese, patients. Improvements in mood represent among the least robust outcomes of TRT and may reflect other, more stable physiologic improvements. Some clinical trials have demonstrated clinical benefits on mood with TRT,[SUP]<a href="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib40" target="_blank">40</a>, <a href="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib54" target="_blank">54</a>, <a href="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib96" target="_blank">96</a>,<a href="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib97" target="_blank">97</a>[/SUP] whereas others have not.[SUP]<a href="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib53" target="_blank">53</a>, <a href="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib56" target="_blank">56</a></p><p></p><p>Source: [/SUP]http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 8439, member: 3"] Sorry for taking a while to reply. We are getting bombarded lately! I have never tried it since it is not available in the US or Mexico. It has been researched in the past 15 years as a male contraceptive. Here is a good summary: [I]7[I][IMG]https://www.nature.com/__chars/alpha/black/ital/base/glyph.gif[/IMG][/I]-methyl-19-nortestosterone (MENT) (Also known as trestolone acetate).[/I] This compound is about 10 times more potent than T in terms of anabolic activities and gonadotropin suppression, is not bound by SHBG in circulation, is not a substrate for 5[I][IMG]https://www.nature.com/__chars/alpha/black/ital/base/glyph.gif[/IMG][/I]-reductase, and has a relatively low potency for stimulation of prostate growth: approximately four times less than that of T.[SUP][URL="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib94"]94[/URL], [URL="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib95"]95[/URL][/SUP]MENT is aromatizable to 7[I][IMG]https://www.nature.com/__chars/alpha/black/ital/base/glyph.gif[/IMG][/I]-methyl estradiol, which may confer beneficial tissue effects via the estrogen receptor. In a randomized crossover trial involving hypogonadal men from two disparate societies (Edinburgh and Hong Kong), patients were allocated to treatment with two MENT acetate 115 mg upper-arm implants for 6 weeks and two i.m. injections of TE 200 mg at 3-week intervals. Compared with a 6-week androgen washout period, both MENT and i.m. TE significantly enhanced sexual function, with no between-group differences.[SUP][URL="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib94"]94[/URL] [/SUP] Although the physiologic benefits of TRT on erectile function as assessed objectively by RigiScan[SUP]®[/SUP] (Timm Medical Systems, Eden Prairie, MN, USA) were significant across treatment centers,[SUP][URL="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib94"]94[/URL][/SUP] other sexual effects were less robust. Both MENT and i.m. TE significantly enhanced self-rated interest in sex, masturbation, sexual intercourse, and overall sexual activity in Scottish, but not Chinese, men. These findings reflect the cultural context and specificity of certain sexual outcome measures. Similar trends were observed with regard to TRT effects on mood: significant increases in self-reported cheerfulness and energy level, coupled with significant decreases in lethargy, depression, and irritability in Scottish, but not Chinese, patients. Improvements in mood represent among the least robust outcomes of TRT and may reflect other, more stable physiologic improvements. Some clinical trials have demonstrated clinical benefits on mood with TRT,[SUP][URL="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib40"]40[/URL], [URL="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib54"]54[/URL], [URL="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib96"]96[/URL],[URL="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib97"]97[/URL][/SUP] whereas others have not.[SUP][URL="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib53"]53[/URL], [URL="http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html#bib56"]56[/URL] Source: [/SUP]http://www.nature.com/ijir/journal/v19/n1/full/3901366a.html [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Has anyone tried trestolone acetate? About to start my experiment
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