Nelson Vergel
Founder, ExcelMale.com
[h=3]Summary[/b][h=4]Objective[/b]The management of male hypogonadotropic hypogonadism (MHH) with gonadotropins is effective in promoting genital development and spermatogenesis. We investigated the changes in SF-36 subscales, including physical, social and psychological QOL, during gonadotropin or testosterone treatment and analyzed the factors that are involved in the outcomes of health-related quality of life (HRQOL) in MHH patients.
[h=4]Patients and Design[/b]Thirty-seven MHH patients (mean age: 26.1 years old) who underwent gonadotropin (n=31) or testosterone treatment (n=6), excluding infertility cases were asked to respond to a SF-36 questionnaire before and every 6 months during the 2-year treatment period. The changes in SF-36 domains and the associations between improvements and patient factors were examined.
[h=4]Results[/b]The scores in all of the SF-36 domains were lower than in the normal Japanese population. In all eight domains, except for bodily pain and social functioning, the mean scores for physical function (PF), role-physical (RP), general health (GH), vitality (VT), role-emotional (RE) and mental health (MH) significantly increased over the course of treatment in patients with gonadotropin. These changes were particularly noticeable in the psychological domains; GH, VT, RE and MH exhibited large increases 18 months after treatment. Testosterone treatment increased only PF and RP domains. In patients with sperm in their ejaculate, the improvements in GH, VT, RE and MH were significantly greater than those who did not exhibit sperm.
[h=4]Conclusion[/b]Gonadotropin treatment for MHH was associated with significant improvements in SF-36 domains. Gonadotropin treatment could prevent negative physical and psychological sequelae in the management of MHH.
http://onlinelibrary.wiley.com/doi/10.1111/cen.12435/abstract
[h=4]Patients and Design[/b]Thirty-seven MHH patients (mean age: 26.1 years old) who underwent gonadotropin (n=31) or testosterone treatment (n=6), excluding infertility cases were asked to respond to a SF-36 questionnaire before and every 6 months during the 2-year treatment period. The changes in SF-36 domains and the associations between improvements and patient factors were examined.
[h=4]Results[/b]The scores in all of the SF-36 domains were lower than in the normal Japanese population. In all eight domains, except for bodily pain and social functioning, the mean scores for physical function (PF), role-physical (RP), general health (GH), vitality (VT), role-emotional (RE) and mental health (MH) significantly increased over the course of treatment in patients with gonadotropin. These changes were particularly noticeable in the psychological domains; GH, VT, RE and MH exhibited large increases 18 months after treatment. Testosterone treatment increased only PF and RP domains. In patients with sperm in their ejaculate, the improvements in GH, VT, RE and MH were significantly greater than those who did not exhibit sperm.
[h=4]Conclusion[/b]Gonadotropin treatment for MHH was associated with significant improvements in SF-36 domains. Gonadotropin treatment could prevent negative physical and psychological sequelae in the management of MHH.
http://onlinelibrary.wiley.com/doi/10.1111/cen.12435/abstract
