Gonadorelin

[trt reznor]

Aside from Cataceous’s experimentations, has anyone had positive experiences with gonadorelin in place of HCG? Testicular size, ejaculate volume, sperm quality? Aromatization issues? Just looking for more detailed feedback as I haven’t found much.

 

[JRoop]

I just received my Gonadorelin today, as my clinic switched from hcg. Hoping to find out more info!

 

[trt reznor]

I just received my Gonadorelin today, as my clinic switched from hcg. Hoping to find out more info!

Nice, what’s your dosing and frequency?

 

[JRoop]

Sorry, just now seen this... It's 2mg, twice a week.

 

[Cataceous]

... It's 2mg, twice a week.

For comparison, a typical pulsed-dose protocol to treat hypogonadotropic hypogonadism uses 10-20 mcg of gonadorelin every 1.5 hours or so. This is 0.16 to 0.32 mg per day, or 1.1 to 2.2 mg per week.

On the plus side, a 2 mg injection is so large that maybe it can overcome pituitary suppression by estradiol and produce some LH and FSH. On the minus side, it's unclear if such infrequent pulses can activate the pituitary to begin with. It will be interesting to see. Also on the minus side, these doses are supraphysiological by a factor of 100 or so. Might there be side effects due to this?

 

[JRoop]

That is very valuable data! So far, I haven't noticed any difference in 'feeling' between the gonadorelin and HCG. So, it would be a 1mg injection done twice weekly, for 2mg total. I'll keep a close watch, and keep everyone updated. Thanks for the feedback!