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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Gonadorelin: Dosage Conversion
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<blockquote data-quote="Cataceous" data-source="post: 184829" data-attributes="member: 38109"><p>I've discussed many of the details <a href="https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results.20864/" target="_blank">here</a>. There are two main problems. First, we don't know the minimum frequency for GnRH to maintain pituitary activity, or simply to provide some subjective benefits. In natural men this hormone is delivered in small pulses every two hours or so. I cite some research showing that pulses at 24 hours could produce activity, but this was starting immediately from normal operation, meaning that a shutdown was still possible if the experiment continued. This protocol of yours is trying to push it out to a single pulse a week, leading to my strong suspicion that it will not be effective.</p><p></p><p>The other significant problem is that estradiol generated by TRT causes negative feedback at the pituitary, acting "to decrease responsiveness to GnRH." If this effect is too strong then the pituitary won't make an LH pulse in response to your GnRH (gonadorelin) pulse. This would have to be overcome by reducing estradiol or by using a SERM.</p><p></p><p>Don't get me wrong: I really like gonadorelin. Using it has correlated with some really nice improvements, while making hCG unnecessary. It would be great to obtain these benefits with a less demanding protocol, but I don't see it happening with such infrequent doses.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 184829, member: 38109"] I've discussed many of the details [URL='https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results.20864/']here[/URL]. There are two main problems. First, we don't know the minimum frequency for GnRH to maintain pituitary activity, or simply to provide some subjective benefits. In natural men this hormone is delivered in small pulses every two hours or so. I cite some research showing that pulses at 24 hours could produce activity, but this was starting immediately from normal operation, meaning that a shutdown was still possible if the experiment continued. This protocol of yours is trying to push it out to a single pulse a week, leading to my strong suspicion that it will not be effective. The other significant problem is that estradiol generated by TRT causes negative feedback at the pituitary, acting "to decrease responsiveness to GnRH." If this effect is too strong then the pituitary won't make an LH pulse in response to your GnRH (gonadorelin) pulse. This would have to be overcome by reducing estradiol or by using a SERM. Don't get me wrong: I really like gonadorelin. Using it has correlated with some really nice improvements, while making hCG unnecessary. It would be great to obtain these benefits with a less demanding protocol, but I don't see it happening with such infrequent doses. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Gonadorelin: Dosage Conversion
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