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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Gonadorelin as HCG alternative?
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<blockquote data-quote="Cataceous" data-source="post: 177256" data-attributes="member: 38109"><p>We were also discussing it in this thread:</p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/clomid-testosterone-why-they-dont-work-together-by-mike-gaiso.9421/post-177225[/URL]</p><p></p><p><em>It's quite likely you will lose all of the benefits you had with hCG. Most guys cannot maintain any significant gonadotropin production on a combination of TRT and Clomid; the relatively high and constant serum testosterone suppresses the hypothalamus, preventing GnRH production. I report in the </em><a href="https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results.20864/" target="_blank"><em>link</em></a><em> above that pituitary activation is possible when GnRH is administered concurrently, but most guys will not find this practical.</em></p><p></p><p><em>Gonadorelin is GnRH. So if they're proposing to give you that along with Clomid then at least they have the right idea. But it probably takes very frequent dosing to get good results. Our bodies normally send out a pulse of GnRH every couple hours or so. In the GnRH trial </em><a href="https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results.20864/" target="_blank"><em>described above</em></a><em> <strong>six daily subQ injections were used,</strong> and in 12 weeks have taken the gonadotropins (LH and FSH) from 0.1 to around 1 mIU/mL. While it's a good start, it doesn't compare to the activation seen with typical hCG doses; hCG is said to be 6-8 times more potent than LH on a per-IU basis.</em></p><p></p><p><em>Gonadorelin alone with testosterone may not be sufficient. There's negative feedback from estradiol at the pituitary that cuts LH and FSH production. The SERM is used to block this feedback.</em></p><p><em></em></p><p><em>Is your clinic stopping hCG due to supply problems? If so can't they just let you buy it from Empower?</em></p></blockquote><p></p>
[QUOTE="Cataceous, post: 177256, member: 38109"] We were also discussing it in this thread: [URL unfurl="true"]https://www.excelmale.com/forum/threads/clomid-testosterone-why-they-dont-work-together-by-mike-gaiso.9421/post-177225[/URL] [I]It's quite likely you will lose all of the benefits you had with hCG. Most guys cannot maintain any significant gonadotropin production on a combination of TRT and Clomid; the relatively high and constant serum testosterone suppresses the hypothalamus, preventing GnRH production. I report in the [/I][URL='https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results.20864/'][I]link[/I][/URL][I] above that pituitary activation is possible when GnRH is administered concurrently, but most guys will not find this practical.[/I] [I]Gonadorelin is GnRH. So if they're proposing to give you that along with Clomid then at least they have the right idea. But it probably takes very frequent dosing to get good results. Our bodies normally send out a pulse of GnRH every couple hours or so. In the GnRH trial [/I][URL='https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results.20864/'][I]described above[/I][/URL][I] [B]six daily subQ injections were used,[/B] and in 12 weeks have taken the gonadotropins (LH and FSH) from 0.1 to around 1 mIU/mL. While it's a good start, it doesn't compare to the activation seen with typical hCG doses; hCG is said to be 6-8 times more potent than LH on a per-IU basis.[/I] [I]Gonadorelin alone with testosterone may not be sufficient. There's negative feedback from estradiol at the pituitary that cuts LH and FSH production. The SERM is used to block this feedback. Is your clinic stopping hCG due to supply problems? If so can't they just let you buy it from Empower?[/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Gonadorelin as HCG alternative?
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