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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
GHK-cu and DHT
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<blockquote data-quote="Cataceous" data-source="post: 220979" data-attributes="member: 38109"><p>I'm not seeing any links to credible research. But definitely skepticism. For example "Cinnamaldehyde_45" on <a href="https://www.reddit.com/r/Peptides/comments/keheib/ghkcu_and_potentially_dangerous_5%CE%B1reductase/" target="_blank">Reddit</a>:</p><p></p><p style="margin-left: 20px"><em>This myth needs to die. Given the amount of skepticism I've seen on this subreddit every other time this topic has been brought up, I would have expected someone else to kill it by now. But since nobody has, I suppose I'll do the honors.</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>GHK-Cu is not a 5-ar inhibitor. As far as I can tell, this notion was confabulated by a few articles that concluded that since finasteride and GHK-Cu can both reverse hair loss, they must operate via the same mechanism, which is scientifically untenable.</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>Finasteride is a steroid. Specifically, an azasteroid, with an amidated (lactamated?) A ring. The only other difference between finasteride and testosterone is the substitution of the beta hydroxyl group on carbon 17 with a beta tert-butylamide substituent. Because of its similar structure, finasteride can bind to the active domain of 5-ar, inhibiting testosterone in the process. GHK can't do this because it's not a steroid—it's a peptide, and a fairly hydrophilic one at that (as demonstrated by its high affinity for Cu2+ ions). So, I wouldn't expect to find it anywhere near heavily-reduced steroids like testosterone and DHT (the latter being fully-reduced) in the cytosol. And I definitely don't see how it could inhibit enzymes with lipid/sterol-based substrates.</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>GHK is also known to operate via numerous anti-fibrotic mechanisms such as decreasing activation of cytokines like TGF-β, which shuts off the anagen phase of the hair cycle.</em></p> <p style="margin-left: 20px"><em>...</em></p> <p style="margin-left: 20px"></p></blockquote><p></p>
[QUOTE="Cataceous, post: 220979, member: 38109"] I'm not seeing any links to credible research. But definitely skepticism. For example "Cinnamaldehyde_45" on [URL='https://www.reddit.com/r/Peptides/comments/keheib/ghkcu_and_potentially_dangerous_5%CE%B1reductase/']Reddit[/URL]: [INDENT][I]This myth needs to die. Given the amount of skepticism I've seen on this subreddit every other time this topic has been brought up, I would have expected someone else to kill it by now. But since nobody has, I suppose I'll do the honors.[/I][/INDENT] [INDENT][/INDENT] [INDENT][I]GHK-Cu is not a 5-ar inhibitor. As far as I can tell, this notion was confabulated by a few articles that concluded that since finasteride and GHK-Cu can both reverse hair loss, they must operate via the same mechanism, which is scientifically untenable.[/I][/INDENT] [INDENT][/INDENT] [INDENT][I]Finasteride is a steroid. Specifically, an azasteroid, with an amidated (lactamated?) A ring. The only other difference between finasteride and testosterone is the substitution of the beta hydroxyl group on carbon 17 with a beta tert-butylamide substituent. Because of its similar structure, finasteride can bind to the active domain of 5-ar, inhibiting testosterone in the process. GHK can't do this because it's not a steroid—it's a peptide, and a fairly hydrophilic one at that (as demonstrated by its high affinity for Cu2+ ions). So, I wouldn't expect to find it anywhere near heavily-reduced steroids like testosterone and DHT (the latter being fully-reduced) in the cytosol. And I definitely don't see how it could inhibit enzymes with lipid/sterol-based substrates.[/I][/INDENT] [INDENT][/INDENT] [INDENT][I]GHK is also known to operate via numerous anti-fibrotic mechanisms such as decreasing activation of cytokines like TGF-β, which shuts off the anagen phase of the hair cycle.[/I][/INDENT] [INDENT][I]...[/I][/INDENT] [INDENT][/INDENT] [/QUOTE]
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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
GHK-cu and DHT
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