I think it really depends on how much one's weight fluctuates. This is one of my issues with TRT as I have several issues; obesity, diabetes, and severe sleep apnea that can lead to hypogonadism and I'm constantly having to adjust doses. 90 days seems realistic as long as one isn't crash dieting. I'm just a little tired of the constant, all be it warranted, changes in T. Feels like my Dr. and I are blindfolded throwing darts.