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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Frequency of HCG *MONOTHERAPY* doses
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<blockquote data-quote="Re-Ride" data-source="post: 95504" data-attributes="member: 8395"><p>Leydig cells, in response to LH, in healthy treatment naive men, produce pulses of testosterone throughout the day peaking in the early am corresponding to pulses of LH produced by the pituitary. </p><p></p><p> hCG acts as an analog to replace low LH in hypogonadic men. In hCG mono the Leydigs are receiving continuous stimulation as long as the hCG serum level is sustained.</p><p></p><p> A notable difference between T replacement and hCG mono therapy is how fast endogenous serum T levels can drop. From 700 to 100 in a matter of hours is possible owing to depletion of serum hCG which has a very short serum half life. This is why you are experiencing dramatic peaks and valleys of energy on twice weekly dosing. </p><p></p><p> Refer to Dr. Saya's study. Most men on hCG mono will inject daily or EOD to maintain therapeutic levels of serum hCG. </p><p></p><p>You could try E3rd day and see how you feel. Every man responds differently so there is no way of knowing whether 100 or 500 iu or more per day is correct. Patience in the order of weeks is required while the Leydigs are growing or coming back online. After that it is fairly easy to adjust your dose by how you respond. Keep in mind though that the time you are investing in hCG mono might better be invested in dialing in TRT which is statistically likely where you will end up. </p><p></p><p> And yes you can feel absolutely fantastic for a period ranging from weeks to months on hCG mono. One explanation is that the many hCG receptors outside of the testes are being stimulated. </p><p>"</p><p>In my case I went almost a year on mono before treatment failure and moving to T cyp injection. Most knowledgeable physicians pay no attention to the old rat studies and do not believe hCG receptor desensitization occurs in humans.</p></blockquote><p></p>
[QUOTE="Re-Ride, post: 95504, member: 8395"] Leydig cells, in response to LH, in healthy treatment naive men, produce pulses of testosterone throughout the day peaking in the early am corresponding to pulses of LH produced by the pituitary. hCG acts as an analog to replace low LH in hypogonadic men. In hCG mono the Leydigs are receiving continuous stimulation as long as the hCG serum level is sustained. A notable difference between T replacement and hCG mono therapy is how fast endogenous serum T levels can drop. From 700 to 100 in a matter of hours is possible owing to depletion of serum hCG which has a very short serum half life. This is why you are experiencing dramatic peaks and valleys of energy on twice weekly dosing. Refer to Dr. Saya's study. Most men on hCG mono will inject daily or EOD to maintain therapeutic levels of serum hCG. You could try E3rd day and see how you feel. Every man responds differently so there is no way of knowing whether 100 or 500 iu or more per day is correct. Patience in the order of weeks is required while the Leydigs are growing or coming back online. After that it is fairly easy to adjust your dose by how you respond. Keep in mind though that the time you are investing in hCG mono might better be invested in dialing in TRT which is statistically likely where you will end up. And yes you can feel absolutely fantastic for a period ranging from weeks to months on hCG mono. One explanation is that the many hCG receptors outside of the testes are being stimulated. " In my case I went almost a year on mono before treatment failure and moving to T cyp injection. Most knowledgeable physicians pay no attention to the old rat studies and do not believe hCG receptor desensitization occurs in humans. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Frequency of HCG *MONOTHERAPY* doses
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