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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Freeing Up Testosterone with Average T Levels and/or Higher SHBG
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<blockquote data-quote="Cataceous" data-source="post: 220852" data-attributes="member: 38109"><p>I also thought more about my argument that Winters' results could be explained by basic principles rather than by some uncharacterized behavior of SHBG. It's based on the two assumptions: First, that in untreated men free testosterone and SHBG are independent random variables. And second, that in treated men total testosterone is an independent variable because doctors are titrating doses to achieve normal levels. An issue with the first assumption is that there probably is an inverse correlation because androgens reduce SHBG production. But because we're talking about the physiological realm, and many factors affect SHBG, I'd suggest the correlation is weak enough to be neglected. A potential problem with the second assumption is the extent to which dose titration is based on symptom relief as opposed to the level of total testosterone. Symptom relief would correlate more with free testosterone. But arguably most doctors are content to push total testosterone back into the normal range and call it a day.</p><p></p><p>The possible complications cut both ways: They may weaken the argument a little but they would also seem to demonstrate enough unaddressed complexity to cast doubt on any interpretation of a small retrospective study like this one.</p><p></p><p>Thoughts?</p></blockquote><p></p>
[QUOTE="Cataceous, post: 220852, member: 38109"] I also thought more about my argument that Winters' results could be explained by basic principles rather than by some uncharacterized behavior of SHBG. It's based on the two assumptions: First, that in untreated men free testosterone and SHBG are independent random variables. And second, that in treated men total testosterone is an independent variable because doctors are titrating doses to achieve normal levels. An issue with the first assumption is that there probably is an inverse correlation because androgens reduce SHBG production. But because we're talking about the physiological realm, and many factors affect SHBG, I'd suggest the correlation is weak enough to be neglected. A potential problem with the second assumption is the extent to which dose titration is based on symptom relief as opposed to the level of total testosterone. Symptom relief would correlate more with free testosterone. But arguably most doctors are content to push total testosterone back into the normal range and call it a day. The possible complications cut both ways: They may weaken the argument a little but they would also seem to demonstrate enough unaddressed complexity to cast doubt on any interpretation of a small retrospective study like this one. Thoughts? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Freeing Up Testosterone with Average T Levels and/or Higher SHBG
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