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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Freeing Up Testosterone with Average T Levels and/or Higher SHBG
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<blockquote data-quote="Cataceous" data-source="post: 220663" data-attributes="member: 38109"><p>The working hypothesis is that in steady state conditions free testosterone is directly proportional to the production rate of endogenous testosterone, or to the dose rate of exogenous testosterone. Only two primary assumptions are necessary: 1) The rate of testosterone entering the system is matched by the rate of testosterone being metabolized and eliminated. 2) The rate of metabolism and elimination is proportional to the level of free testosterone, following the <a href="https://en.wikipedia.org/wiki/Law_of_mass_action" target="_blank">law of mass action</a>. A secondary assumption is that the underlying rate constant for metabolic clearance is relatively static. There are situations in which this constant changes dramatically, presumably including damage to the liver. But we'd hope these would not be common.</p><p></p><p>If the hypothesis is correct then it's clear that SHBG has little effect on free testosterone. Also, there are so many factors affecting the production rate of SHBG that it probably could not serve as a viable regulator anyway. And SHBG has a half-life of about a week, so it would be a very slow regulator as well.</p><p></p><p>Think of SHBG as a reservoir for testosterone. If you have high SHBG then you have a big reservoir, and consequently higher total testosterone as well. With low SHBG your reservoir is small and therefore your total testosterone is relatively low.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 220663, member: 38109"] The working hypothesis is that in steady state conditions free testosterone is directly proportional to the production rate of endogenous testosterone, or to the dose rate of exogenous testosterone. Only two primary assumptions are necessary: 1) The rate of testosterone entering the system is matched by the rate of testosterone being metabolized and eliminated. 2) The rate of metabolism and elimination is proportional to the level of free testosterone, following the [URL='https://en.wikipedia.org/wiki/Law_of_mass_action']law of mass action[/URL]. A secondary assumption is that the underlying rate constant for metabolic clearance is relatively static. There are situations in which this constant changes dramatically, presumably including damage to the liver. But we'd hope these would not be common. If the hypothesis is correct then it's clear that SHBG has little effect on free testosterone. Also, there are so many factors affecting the production rate of SHBG that it probably could not serve as a viable regulator anyway. And SHBG has a half-life of about a week, so it would be a very slow regulator as well. Think of SHBG as a reservoir for testosterone. If you have high SHBG then you have a big reservoir, and consequently higher total testosterone as well. With low SHBG your reservoir is small and therefore your total testosterone is relatively low. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Freeing Up Testosterone with Average T Levels and/or Higher SHBG
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