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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Freeing Up Testosterone with Average T Levels and/or Higher SHBG
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<blockquote data-quote="Cataceous" data-source="post: 220573" data-attributes="member: 38109"><p>"If you consider total testosterone as essentially fixed then you're left with comparing this constant to SHBG, which still has a normal distribution."</p><p></p><p>Poor choice of words on my part, as I was thinking more about mean values for total testosterone that would be acquired at multiple SHBG values if N were large enough. Instead, total testosterone might be considered as a separate random variable, subject to the vagaries of the particular doctors overseeing the TRT, but independent of SHBG. If the doctors were instead targeting free testosterone then I expect total testosterone's correlation with SHBG would return.</p><p></p><p></p><p>I think it's possible the time constants involved in HPTA regulation are long enough that even in more realistic SHBG-manipulation scenarios there would not be a lot of hysteresis. Natesto is a possible proxy, with multiple daily doses not being too suppressive. It's true that in the thought experiment the step change in SHBG production is assumed so that there is no change in equilibrium.</p><p></p><p>A couple of more realistic scenarios are an injection of SHBG or the administration of a drug that affects SHBG in relative isolation. An injection of SHBG would somewhat imitate a step increase. The SHBG would start sucking up the free hormones, which in a normal HPTA would stimulate additional testosterone production. This would taper off as total testosterone reaches a new value that's consistent with the body's free testosterone set point and the amount of SHBG. I'm not sure what happens with the other complications: Is there a set point for SHBG that reduces production? What is its time constant? How complicated is the function modeling the return of SHBG to baseline?</p></blockquote><p></p>
[QUOTE="Cataceous, post: 220573, member: 38109"] "If you consider total testosterone as essentially fixed then you're left with comparing this constant to SHBG, which still has a normal distribution." Poor choice of words on my part, as I was thinking more about mean values for total testosterone that would be acquired at multiple SHBG values if N were large enough. Instead, total testosterone might be considered as a separate random variable, subject to the vagaries of the particular doctors overseeing the TRT, but independent of SHBG. If the doctors were instead targeting free testosterone then I expect total testosterone's correlation with SHBG would return. I think it's possible the time constants involved in HPTA regulation are long enough that even in more realistic SHBG-manipulation scenarios there would not be a lot of hysteresis. Natesto is a possible proxy, with multiple daily doses not being too suppressive. It's true that in the thought experiment the step change in SHBG production is assumed so that there is no change in equilibrium. A couple of more realistic scenarios are an injection of SHBG or the administration of a drug that affects SHBG in relative isolation. An injection of SHBG would somewhat imitate a step increase. The SHBG would start sucking up the free hormones, which in a normal HPTA would stimulate additional testosterone production. This would taper off as total testosterone reaches a new value that's consistent with the body's free testosterone set point and the amount of SHBG. I'm not sure what happens with the other complications: Is there a set point for SHBG that reduces production? What is its time constant? How complicated is the function modeling the return of SHBG to baseline? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Freeing Up Testosterone with Average T Levels and/or Higher SHBG
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