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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Freeing Up Testosterone with Average T Levels and/or Higher SHBG
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<blockquote data-quote="Cataceous" data-source="post: 220536" data-attributes="member: 38109"><p>Now that I've had a chance to look beyond the abstract I see there is a solid underlying reference from Vermeulen suggesting the existence of an additional factor in obesity-linked hypogonadism beyond enhanced aromatization. Winters touches on another explanation:</p><p></p><p style="margin-left: 20px"><em>... leptin activates kisspeptin neurons to stimulate GnRH [17], and leptin deficiency is associated with hypogonadotropic hypogonadism [18]. Moreover, leptin treatment restores the testosterone deficiency that occurs with fasting [19]. As obese individuals are viewed as resistant to leptin, leptin resistance may also play a role in AOH.</em></p><p></p><p>I'm puzzling over this "idea that SHBG regulates testicular negative feedback either directly or by modulating the entry of testosterone or estradiol into cells in the hypothalamus and/or pituitary..." An interpretation of recent research is that SHBG helps get androgens (and estrogens?) into cells, and intracellularly may also help these steroids stay unmetabolized long enough to do something useful. When it comes to negative feedback caused by these hormones, the effect of SHBG would seem to be opposite the hypothesis, with higher levels promoting stronger negative feedback and lower testosterone. Or am I missing something?</p></blockquote><p></p>
[QUOTE="Cataceous, post: 220536, member: 38109"] Now that I've had a chance to look beyond the abstract I see there is a solid underlying reference from Vermeulen suggesting the existence of an additional factor in obesity-linked hypogonadism beyond enhanced aromatization. Winters touches on another explanation: [INDENT][I]... leptin activates kisspeptin neurons to stimulate GnRH [17], and leptin deficiency is associated with hypogonadotropic hypogonadism [18]. Moreover, leptin treatment restores the testosterone deficiency that occurs with fasting [19]. As obese individuals are viewed as resistant to leptin, leptin resistance may also play a role in AOH.[/I][/INDENT] I'm puzzling over this "idea that SHBG regulates testicular negative feedback either directly or by modulating the entry of testosterone or estradiol into cells in the hypothalamus and/or pituitary..." An interpretation of recent research is that SHBG helps get androgens (and estrogens?) into cells, and intracellularly may also help these steroids stay unmetabolized long enough to do something useful. When it comes to negative feedback caused by these hormones, the effect of SHBG would seem to be opposite the hypothesis, with higher levels promoting stronger negative feedback and lower testosterone. Or am I missing something? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Freeing Up Testosterone with Average T Levels and/or Higher SHBG
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