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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Freeing Up Testosterone with Average T Levels and/or Higher SHBG
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<blockquote data-quote="Cataceous" data-source="post: 220419" data-attributes="member: 38109"><p>They have the causality backwards. Keep in mind that the body is basically regulating free testosterone, and those of us on TRT are doing something similar by taking fixed doses at regular intervals. So in these thought experiments it's reasonable to assert that free testosterone is held constant. Under these circumstances an increase in SHBG causes an increase in total testosterone, while a decrease in SHBG causes a decrease in total testosterone. Contrary to popular belief, a change in SHBG in isolation likely does not affect free testosterone at the new equilibrium.</p><p></p><p>However: Androgens do tend to lower SHBG. it's very common for guys starting TRT to see major reductions in SHBG. The increasing free testosterone has this effect on the liver. Estrogens are the opposite; increasing—free—levels tend to increase SHBG. Those of us who experience very low estradiol will often see SHBG greatly reduced as well.</p><p></p><p></p><p>If your free testosterone is low then you are not making enough testosterone. Production is what drives free testosterone. Total testosterone just goes along for the ride, effectively a dependent variable of free T, SHBG, albumin, etc. The free hormone hypothesis is still hanging in there. Yes, there is added complexity involving the binding proteins, but free testosterone correlates well with outcomes.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 220419, member: 38109"] They have the causality backwards. Keep in mind that the body is basically regulating free testosterone, and those of us on TRT are doing something similar by taking fixed doses at regular intervals. So in these thought experiments it's reasonable to assert that free testosterone is held constant. Under these circumstances an increase in SHBG causes an increase in total testosterone, while a decrease in SHBG causes a decrease in total testosterone. Contrary to popular belief, a change in SHBG in isolation likely does not affect free testosterone at the new equilibrium. However: Androgens do tend to lower SHBG. it's very common for guys starting TRT to see major reductions in SHBG. The increasing free testosterone has this effect on the liver. Estrogens are the opposite; increasing—free—levels tend to increase SHBG. Those of us who experience very low estradiol will often see SHBG greatly reduced as well. If your free testosterone is low then you are not making enough testosterone. Production is what drives free testosterone. Total testosterone just goes along for the ride, effectively a dependent variable of free T, SHBG, albumin, etc. The free hormone hypothesis is still hanging in there. Yes, there is added complexity involving the binding proteins, but free testosterone correlates well with outcomes. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Freeing Up Testosterone with Average T Levels and/or Higher SHBG
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