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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
For discussion: Estrogen via the testes (not Aromatase)
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<blockquote data-quote="Dr Justin Saya MD" data-source="post: 30643" data-attributes="member: 12687"><p>This is a minor point, but the intratesticular conversion of testosterone to estrogen is STILL done by the aromatase enzyme. The problem is that LH has been shown to increase the INTRAtesticular aromatization of T->E. Thus, as astutely pointed out, it would follow that the LH analog hCG would also increase this intratesticular aromatization. </p><p></p><p>This means that the aromatization rate in the testes after administration of LH/hCG is likely higher than the rest of the body's overall aromatization rate....so an aromatase inhibitor will simply be less effective (although still have some efficacy) at controlling this intratesticular aromatization. Think of the testes as a micro-environment where the aromatase enzyme has an unfair advantage over its counterpart, aromatase inhibitor, when hCG is administered.</p><p></p><p>Indeed the conversion to estradiol ALWAYS requires aromatase, it's just a question of WHERE this conversion occurs and the differences in the aromatase activity among various tissues.</p><p></p><p>DHEA -> androstenediONE-> (aromatase)-> estrone -> estradiol.</p><p></p><p>DHEA-> androstenedIOL -> testosterone -> (aromatase)-> estradiol.</p></blockquote><p></p>
[QUOTE="Dr Justin Saya MD, post: 30643, member: 12687"] This is a minor point, but the intratesticular conversion of testosterone to estrogen is STILL done by the aromatase enzyme. The problem is that LH has been shown to increase the INTRAtesticular aromatization of T->E. Thus, as astutely pointed out, it would follow that the LH analog hCG would also increase this intratesticular aromatization. This means that the aromatization rate in the testes after administration of LH/hCG is likely higher than the rest of the body's overall aromatization rate....so an aromatase inhibitor will simply be less effective (although still have some efficacy) at controlling this intratesticular aromatization. Think of the testes as a micro-environment where the aromatase enzyme has an unfair advantage over its counterpart, aromatase inhibitor, when hCG is administered. Indeed the conversion to estradiol ALWAYS requires aromatase, it's just a question of WHERE this conversion occurs and the differences in the aromatase activity among various tissues. DHEA -> androstenediONE-> (aromatase)-> estrone -> estradiol. DHEA-> androstenedIOL -> testosterone -> (aromatase)-> estradiol. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
For discussion: Estrogen via the testes (not Aromatase)
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