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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
First post. Can’t get E2 under control, starting to worry
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<blockquote data-quote="Cataceous" data-source="post: 277134" data-attributes="member: 38109"><p>If you had been following the discussions on ExcelMale then you would know that it is dated thinking to believe that an effective reduction in SHBG raises free testosterone. Here's a thought experiment for you: Imagine a guy with a normal HPTA that is regulating for its desired level of free testosterone. In order to use the Vermeulen calculator, assume that free testosterone is 15.1 ng/dL, TT is 650 ng/dL, ALB is 4.3 g/dL and SHBG is 30 nMol/L. The calculator tells us that 295 ng/dL of the total testosterone is bound to SHBG. Now imagine removing half of the guy's SHBG, including what's bound to it. What is the result? For one thing, SHBG is reduced to 15 nMol/L. My question for you: what pressure is there on free testosterone to change? The answer is none. The HPTA is still happy because it is seeing the desired 15.1 ng/dL of free T. With the SHBG we removed we have also removed 295/2 = 147.5 ng/dL of total testosterone, leaving 650 - 147.5 = 502.5 ng/dL. Is this a stable equilibrium? Yes, according to Vermeulen these new values for SHBG and TT result in the same 15.1 ng/dL of free testosterone.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 277134, member: 38109"] If you had been following the discussions on ExcelMale then you would know that it is dated thinking to believe that an effective reduction in SHBG raises free testosterone. Here's a thought experiment for you: Imagine a guy with a normal HPTA that is regulating for its desired level of free testosterone. In order to use the Vermeulen calculator, assume that free testosterone is 15.1 ng/dL, TT is 650 ng/dL, ALB is 4.3 g/dL and SHBG is 30 nMol/L. The calculator tells us that 295 ng/dL of the total testosterone is bound to SHBG. Now imagine removing half of the guy's SHBG, including what's bound to it. What is the result? For one thing, SHBG is reduced to 15 nMol/L. My question for you: what pressure is there on free testosterone to change? The answer is none. The HPTA is still happy because it is seeing the desired 15.1 ng/dL of free T. With the SHBG we removed we have also removed 295/2 = 147.5 ng/dL of total testosterone, leaving 650 - 147.5 = 502.5 ng/dL. Is this a stable equilibrium? Yes, according to Vermeulen these new values for SHBG and TT result in the same 15.1 ng/dL of free testosterone. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
First post. Can’t get E2 under control, starting to worry
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