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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
First post. Can’t get E2 under control, starting to worry
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<blockquote data-quote="RobRoy" data-source="post: 277087" data-attributes="member: 42893"><p>We use it to improve dyslipidemia because it is metabolized in the liver and improves our lipid profile. That's why we use it. But we're also all saying is that what you're measuring the serum is no reflection of what's at the tissue level. It's a meaningless measurement. And don't extrapolate what happens to obese men that have high estradiol that are not on testosterone what happens when we give obese men testosterone and then raise their estradiol. And maybe those men that are injecting estradiol to get the improvement in the areas that you're mentioning should try increasing estradiol by raising their free testosterone level. And when we give estradiol to men that want to transition it chemically castrates them. Its negative feedback shuts down testosterone production. In fact, medicine has utilized estrogen to chemically castrate men with prostate cancer. So what you're doing is trying to look at baseline observations of high estradiol and men, and apply that to raising estradiol in men by giving them testosterone. Yes we can agree that high estradiol in obese men will decrease testosterone production. But we also have to agree that when we give men testosterone and raise estradiol in men that already have high estradiol it doesn't cause any harm, but instead benefit. I can literally provide you with dozens of studies, giving testosterone to morbidly obese man that had high estradiol levels because they were morbidly obese, and provided them with nothing but benefit. But then, when we give men testosterone and block estradiol with an aromatase inhibitor, they get fatter. It's because what you're measuring the serum is spill over as well as what's produced peripherally, and we try to block what we are measuring in the serum, we cause damage at the tissue level. So, when we raise estradiol with testosterone, or we take estradiol, it has a positive effect on our lipid profile and provides us with cardiovascular protection. And that's due to How estradiol is metabolized. And a whole other topic is the non-genomic effects of testosterone and estradiol, etc. But we're talking about is the genomic effects </p><p>And as far as spill over goes once again, you're not understanding that what's in the serum is in the serum and not doing anything because you can measure it in the serum. Where estradiol is exerting his actions is in the tissues. Testosterone is converted into estradiol in the tissues where it binds to its receptor. You can't measure that.</p></blockquote><p></p>
[QUOTE="RobRoy, post: 277087, member: 42893"] We use it to improve dyslipidemia because it is metabolized in the liver and improves our lipid profile. That's why we use it. But we're also all saying is that what you're measuring the serum is no reflection of what's at the tissue level. It's a meaningless measurement. And don't extrapolate what happens to obese men that have high estradiol that are not on testosterone what happens when we give obese men testosterone and then raise their estradiol. And maybe those men that are injecting estradiol to get the improvement in the areas that you're mentioning should try increasing estradiol by raising their free testosterone level. And when we give estradiol to men that want to transition it chemically castrates them. Its negative feedback shuts down testosterone production. In fact, medicine has utilized estrogen to chemically castrate men with prostate cancer. So what you're doing is trying to look at baseline observations of high estradiol and men, and apply that to raising estradiol in men by giving them testosterone. Yes we can agree that high estradiol in obese men will decrease testosterone production. But we also have to agree that when we give men testosterone and raise estradiol in men that already have high estradiol it doesn't cause any harm, but instead benefit. I can literally provide you with dozens of studies, giving testosterone to morbidly obese man that had high estradiol levels because they were morbidly obese, and provided them with nothing but benefit. But then, when we give men testosterone and block estradiol with an aromatase inhibitor, they get fatter. It's because what you're measuring the serum is spill over as well as what's produced peripherally, and we try to block what we are measuring in the serum, we cause damage at the tissue level. So, when we raise estradiol with testosterone, or we take estradiol, it has a positive effect on our lipid profile and provides us with cardiovascular protection. And that's due to How estradiol is metabolized. And a whole other topic is the non-genomic effects of testosterone and estradiol, etc. But we're talking about is the genomic effects And as far as spill over goes once again, you're not understanding that what's in the serum is in the serum and not doing anything because you can measure it in the serum. Where estradiol is exerting his actions is in the tissues. Testosterone is converted into estradiol in the tissues where it binds to its receptor. You can't measure that. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
First post. Can’t get E2 under control, starting to worry
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