ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
First post. Can’t get E2 under control, starting to worry
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="RobRoy" data-source="post: 277054" data-attributes="member: 42893"><p>It's because the cream will raise free testosterone levels better than injections for any given total in the same man. It's the free testosterone cause in the effects not the DHT you're measuring in the serum because that is not reflective of the DHT at the tissue level. Just like measuring estradiol in the serum is no reflection of the estradiol at the tissue level. It's just essentially what is produced peripherally, as well as what has escaped local metabolism. The cream will raise free, testosterone levels and maintain them daily since it is a twice daily application. Most men don't inject daily, so they don't have free testosterone levels that are consistently optimal. It is the free testosterone that enters the tissues where it is converted into DHT or estradiol to exert effects. Not what you measure the serum. So it's the consistent increase in free testosterone levels that causes the effects you're mentioning not the raising of the DHT or estradiol for that matter. If we give DHT to men not on testosterone, and raise their levels 10 times normal it doesn't have any effect on intracellular DHT levels in DHT sensitive tissues. When we do this for two years, it also doesn't have any effect on hair loss, acne, or other skin pathology. What it does do though is significantly inhibit testosterone production, and when you take DHT by itself, you're going to significantly lower your testosterone and estradiol levels. DHT has a negative feedback on testosterone production just like testosterone and estradiol have a negative feedback. I think the real issue here is the relevance of measuring DHT and estradiol in general. Their measurement in the serum has no reflection on tissue levels. When we lower the serum levels of DHT and estradiol we cause harm because we then lower it in the tissues where it is needed and exerts its effects. Proviron is also not bioidentical DHT BTW just like dianabol is not testosterone etc... Can't use a synthetic anabolic steroid and compare it to a bio identical hormone. You've got to understand what's going to be discussed in an upcoming video as well, with regard to androgen receptor, saturation, and enzyme saturation. So we can raise DHT four or five times normal giving a transdermal cream, but let me tell you another reason it has no effect on the tissues, in addition to the fact that the tissues tightly regulate their intracellar DHT levels. The reason is that there are only so many receptors for the DHT to bind to and once those receptors are fully bound with DHT no matter how high you raise DHT it can't exert an effect. You can only raise DHT to a certain point as well, because the five alpha reductase enzyme becomes fully saturated. And DHT sensitive tissues are fully stimulated at a fairly low, testosterone level. So what's your measuring serum is excess that can't exert an effect because they can't bind to a receptor because the receptors are fully saturated. Just like raising testosterone to 10,000 or 30,000 won't have an affect on how someone feels because all the receptors are fully saturated at a much much lower level. Yes you can continue to increase lean muscle mass because androgen receptors are up regulated in skeletal muscle. They are not up regulator in the brain or prostate etc...</p></blockquote><p></p>
[QUOTE="RobRoy, post: 277054, member: 42893"] It's because the cream will raise free testosterone levels better than injections for any given total in the same man. It's the free testosterone cause in the effects not the DHT you're measuring in the serum because that is not reflective of the DHT at the tissue level. Just like measuring estradiol in the serum is no reflection of the estradiol at the tissue level. It's just essentially what is produced peripherally, as well as what has escaped local metabolism. The cream will raise free, testosterone levels and maintain them daily since it is a twice daily application. Most men don't inject daily, so they don't have free testosterone levels that are consistently optimal. It is the free testosterone that enters the tissues where it is converted into DHT or estradiol to exert effects. Not what you measure the serum. So it's the consistent increase in free testosterone levels that causes the effects you're mentioning not the raising of the DHT or estradiol for that matter. If we give DHT to men not on testosterone, and raise their levels 10 times normal it doesn't have any effect on intracellular DHT levels in DHT sensitive tissues. When we do this for two years, it also doesn't have any effect on hair loss, acne, or other skin pathology. What it does do though is significantly inhibit testosterone production, and when you take DHT by itself, you're going to significantly lower your testosterone and estradiol levels. DHT has a negative feedback on testosterone production just like testosterone and estradiol have a negative feedback. I think the real issue here is the relevance of measuring DHT and estradiol in general. Their measurement in the serum has no reflection on tissue levels. When we lower the serum levels of DHT and estradiol we cause harm because we then lower it in the tissues where it is needed and exerts its effects. Proviron is also not bioidentical DHT BTW just like dianabol is not testosterone etc... Can't use a synthetic anabolic steroid and compare it to a bio identical hormone. You've got to understand what's going to be discussed in an upcoming video as well, with regard to androgen receptor, saturation, and enzyme saturation. So we can raise DHT four or five times normal giving a transdermal cream, but let me tell you another reason it has no effect on the tissues, in addition to the fact that the tissues tightly regulate their intracellar DHT levels. The reason is that there are only so many receptors for the DHT to bind to and once those receptors are fully bound with DHT no matter how high you raise DHT it can't exert an effect. You can only raise DHT to a certain point as well, because the five alpha reductase enzyme becomes fully saturated. And DHT sensitive tissues are fully stimulated at a fairly low, testosterone level. So what's your measuring serum is excess that can't exert an effect because they can't bind to a receptor because the receptors are fully saturated. Just like raising testosterone to 10,000 or 30,000 won't have an affect on how someone feels because all the receptors are fully saturated at a much much lower level. Yes you can continue to increase lean muscle mass because androgen receptors are up regulated in skeletal muscle. They are not up regulator in the brain or prostate etc... [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
First post. Can’t get E2 under control, starting to worry
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top