ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
First post. Can’t get E2 under control, starting to worry
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="FunkOdyssey" data-source="post: 276950" data-attributes="member: 44064"><p>Benzyl benzoate greatly speeds up the absorption of testosterone while it is present. However, the benzyl benzoate itself is absorbed quickly, and when it is gone from the solution, the rate of absorption for the remaining testosterone in the oil depot slows down. Consequently, you have a biphasic pattern of absorption with a BB formula: a fast spike in the beginning, followed by the slower, normal release pattern for the unadulterated ester.</p><p></p><p>Benzyl benzoate is rapidly hydrolyzed to benzyl alcohol in the body, so we want to consider the effects of benzyl alcohol. From the Encylopedia of Toxicology:</p><p></p><p><em>High doses of benzyl alcohol cause nausea, vomiting, diarrhea, <a href="https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/central-nervous-system" target="_blank">CNS</a> depression, and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/vertigo" target="_blank">vertigo</a>. Dilute solutions (1%) produce <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/local-anesthesia" target="_blank">local anesthesia</a> and slight irritation when instilled into the eye. Pure benzyl alcohol produces <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/cornea-necrosis" target="_blank">corneal necrosis</a>. Following acute exposure lethargy, <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/epileptic-seizure" target="_blank">seizures</a>, <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/cerebral-hemorrhage" target="_blank">intraventricular hemorrhage</a>, and neurological <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/sequela" target="_blank">sequelae</a> (cerebral palsy, developmental delay) have been seen in <a href="https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/neonate" target="_blank">neonates</a> with parenteral benzyl alcohol toxicity. <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/metabolic-acidosis" target="_blank">Metabolic acidosis</a> was a common finding with parenteral toxicity in neonates. <a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/thrombocytopenia" target="_blank">Thrombocytopenia</a> was a delayed feature of parenteral toxicity in neonates. Deaths associated with intravenous or endotracheal administration of benzyl alcohol-containing solutions in neonates were preceded by symptoms of respiratory distress progressing to gasping respirations, <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/metabolic-acidosis" target="_blank">metabolic acidosis</a>, CNS depression, hypotension, renal failure, and occasionally seizures and intracranial hemorrhage. Thrombocytopenia was a delayed feature of parenteral toxicity in neonates. Severe striated <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/bullous-keratopathy" target="_blank">keratopathy</a>, progressing to chronic edema of cornea, was noted following <a href="https://www.sciencedirect.com/topics/chemistry/intraocular" target="_blank">intraocular</a> use of a sodium chloride solution containing 2% benzyl alcohol.</em></p><p></p><p>A typical dose of testosterone cypionate delivers more benzyl benzoate and benzyl alcohol than testosterone. For each 100 mg of testosterone, you get about 110 mg of these excipients.</p></blockquote><p></p>
[QUOTE="FunkOdyssey, post: 276950, member: 44064"] Benzyl benzoate greatly speeds up the absorption of testosterone while it is present. However, the benzyl benzoate itself is absorbed quickly, and when it is gone from the solution, the rate of absorption for the remaining testosterone in the oil depot slows down. Consequently, you have a biphasic pattern of absorption with a BB formula: a fast spike in the beginning, followed by the slower, normal release pattern for the unadulterated ester. Benzyl benzoate is rapidly hydrolyzed to benzyl alcohol in the body, so we want to consider the effects of benzyl alcohol. From the Encylopedia of Toxicology: [I]High doses of benzyl alcohol cause nausea, vomiting, diarrhea, [URL='https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/central-nervous-system']CNS[/URL] depression, and [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/vertigo']vertigo[/URL]. Dilute solutions (1%) produce [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/local-anesthesia']local anesthesia[/URL] and slight irritation when instilled into the eye. Pure benzyl alcohol produces [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/cornea-necrosis']corneal necrosis[/URL]. Following acute exposure lethargy, [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/epileptic-seizure']seizures[/URL], [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/cerebral-hemorrhage']intraventricular hemorrhage[/URL], and neurological [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/sequela']sequelae[/URL] (cerebral palsy, developmental delay) have been seen in [URL='https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/neonate']neonates[/URL] with parenteral benzyl alcohol toxicity. [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/metabolic-acidosis']Metabolic acidosis[/URL] was a common finding with parenteral toxicity in neonates. [URL='https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/thrombocytopenia']Thrombocytopenia[/URL] was a delayed feature of parenteral toxicity in neonates. Deaths associated with intravenous or endotracheal administration of benzyl alcohol-containing solutions in neonates were preceded by symptoms of respiratory distress progressing to gasping respirations, [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/metabolic-acidosis']metabolic acidosis[/URL], CNS depression, hypotension, renal failure, and occasionally seizures and intracranial hemorrhage. Thrombocytopenia was a delayed feature of parenteral toxicity in neonates. Severe striated [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/bullous-keratopathy']keratopathy[/URL], progressing to chronic edema of cornea, was noted following [URL='https://www.sciencedirect.com/topics/chemistry/intraocular']intraocular[/URL] use of a sodium chloride solution containing 2% benzyl alcohol.[/I] A typical dose of testosterone cypionate delivers more benzyl benzoate and benzyl alcohol than testosterone. For each 100 mg of testosterone, you get about 110 mg of these excipients. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
X (Twitter)
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
First post. Can’t get E2 under control, starting to worry
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top