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To me it seems a little questionable. "Safely" tolerating the treatment in the short term does not imply long-term safety. Recall @tareload's graphs suggesting that risk can accumulate over years to decades. There should also be more medical curiosity about why the guy appears to need triple the typical heathy production rate. In any case, I'm not suggesting that treatment be denied if all else has failed, but the patient must be well-informed.